Nancy Maizels
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Explore the profile of Nancy Maizels including associated specialties, affiliations and a list of published articles.
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63
Citations
2990
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Recent Articles
1.
Torrecilla I, Ruggiano A, Kiianitsa K, Aljarbou F, Lascaux P, Hoslett G, et al.
Nucleic Acids Res
. 2023 Dec;
52(2):525-547.
PMID: 38084926
DNA-protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication, transcription and DNA damage...
2.
Nitiss J, Kiianitsa K, Sun Y, Nitiss K, Maizels N
Curr Protoc
. 2021 Oct;
1(10):e250.
PMID: 34606690
Topoisomerases are enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of DNA topoisomerases: type I enzymes, which make single-stranded...
3.
Zhang Y, Davis L, Maizels N
PLoS Genet
. 2021 Apr;
17(4):e1009329.
PMID: 33857147
Nicks are the most frequent form of DNA damage and a potential source of mutagenesis in human cells. By deep sequencing, we have identified factors and pathways that promote and...
4.
Kiianitsa K, Zhang Y, Maizels N
DNA Repair (Amst)
. 2020 Oct;
96:102977.
PMID: 33039802
The nucleoside analog 5-aza-2'-deoxycytidine (5-aza-dC) is used to treat some hematopoietic malignancies. The mechanism of cell killing depends upon DNMT1, but is otherwise not clearly defined. Here we show that...
5.
Davis L, Khoo K, Zhang Y, Maizels N
Proc Natl Acad Sci U S A
. 2020 Sep;
117(37):22900-22909.
PMID: 32873648
Interhomolog recombination (IHR) occurs spontaneously in somatic human cells at frequencies that are low but sufficient to ameliorate some genetic diseases caused by heterozygous mutations or autosomal dominant mutations. Here...
6.
Sinha D, Kiianitsa K, Sherman D, Maizels N
Anal Biochem
. 2020 Aug;
608:113827.
PMID: 32738213
Topoisomerases are proven drug targets, but antibiotics that poison bacterial Topoisomerase 1 (Top1) have yet to be discovered. We have developed a rapid and direct assay for quantification of Top1-DNA...
7.
Kiianitsa K, Maizels N
DNA Repair (Amst)
. 2020 Feb;
89:102825.
PMID: 32109764
Proteins form adducts with nucleic acids in a variety of contexts, and these adducts may be cytotoxic if not repaired. Here we apply a proteomic approach to identification of proteins...
8.
Gray L, Lombardi E, Verga D, Nicolas A, Teulade-Fichou M, Londono-Vallejo A, et al.
Cell Chem Biol
. 2019 Nov;
26(12):1681-1691.e5.
PMID: 31668518
Heme is an essential cofactor for many enzymes, but free heme is toxic and its levels are tightly regulated. G-quadruplexes bind heme avidly in vitro, raising the possibility that they...
9.
Le Q, Maizels N
PLoS Genet
. 2019 Feb;
15(2):e1007968.
PMID: 30811383
Activation-induced deaminase (AID) converts C to U and 5-methyl-C to T. These mutagenic activities are critical to immunoglobulin (Ig) gene diversification and epigenetic reprogramming, but they must be tightly controlled...
10.
Olson H, Davis L, Kiianitsa K, Khoo K, Liu Y, Knijnenburg T, et al.
Nucleic Acids Res
. 2018 Aug;
46(18):9496-9509.
PMID: 30107528
RECQ5 (RECQL5) is one of several human helicases that dissociates RAD51-DNA filaments. The gene that encodes RECQ5 is frequently amplified in human tumors, but it is not known whether amplification...