» Articles » PMID: 17145710

IntAct--open Source Resource for Molecular Interaction Data

Abstract

IntAct is an open source database and software suite for modeling, storing and analyzing molecular interaction data. The data available in the database originates entirely from published literature and is manually annotated by expert biologists to a high level of detail, including experimental methods, conditions and interacting domains. The database features over 126,000 binary interactions extracted from over 2100 scientific publications and makes extensive use of controlled vocabularies. The web site provides tools allowing users to search, visualize and download data from the repository. IntAct supports and encourages local installations as well as direct data submission and curation collaborations. IntAct source code and data are freely available from http://www.ebi.ac.uk/intact.

Citing Articles

AI approaches for the discovery and validation of drug targets.

Wenteler A, Cabrera C, Wei W, Neduva V, Barnes M Camb Prism Precis Med. 2024; 2:e7.

PMID: 39258224 PMC: 11383977. DOI: 10.1017/pcm.2024.4.


Cell-cell communication: new insights and clinical implications.

Su J, Song Y, Zhu Z, Huang X, Fan J, Qiao J Signal Transduct Target Ther. 2024; 9(1):196.

PMID: 39107318 PMC: 11382761. DOI: 10.1038/s41392-024-01888-z.


PPGR: a comprehensive perennial plant genomes and regulation database.

Yang S, Zong W, Shi L, Li R, Ma Z, Ma S Nucleic Acids Res. 2023; 52(D1):D1588-D1596.

PMID: 37933857 PMC: 10767873. DOI: 10.1093/nar/gkad963.


Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity.

Connors J, Cusimano G, Mege N, Woloszczuk K, Konopka E, Bell M Hum Vaccin Immunother. 2023; 19(3):2267295.

PMID: 37885158 PMC: 10760375. DOI: 10.1080/21645515.2023.2267295.


Insight from sirtuins interactome: topological prominence and multifaceted roles of SIRT1 in modulating immunity, aging and cancer.

Zulkifli N, Zulkifle N Genomics Inform. 2023; 21(2):e23.

PMID: 37557919 PMC: 10326532. DOI: 10.5808/gi.23003.


References
1.
Lappe M, Holm L . Unraveling protein interaction networks with near-optimal efficiency. Nat Biotechnol. 2003; 22(1):98-103. DOI: 10.1038/nbt921. View

2.
Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S . IntAct: an open source molecular interaction database. Nucleic Acids Res. 2003; 32(Database issue):D452-5. PMC: 308786. DOI: 10.1093/nar/gkh052. View

3.
Mulder N, Apweiler R, Attwood T, Bairoch A, Bateman A, Binns D . InterPro, progress and status in 2005. Nucleic Acids Res. 2004; 33(Database issue):D201-5. PMC: 540060. DOI: 10.1093/nar/gki106. View

4.
Alfarano C, Andrade C, Anthony K, Bahroos N, Bajec M, Bantoft K . The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res. 2004; 33(Database issue):D418-24. PMC: 540005. DOI: 10.1093/nar/gki051. View

5.
Joshi-Tope G, Gillespie M, Vastrik I, DEustachio P, Schmidt E, de Bono B . Reactome: a knowledgebase of biological pathways. Nucleic Acids Res. 2004; 33(Database issue):D428-32. PMC: 540026. DOI: 10.1093/nar/gki072. View