A Simple Asymmetric Organocatalytic Approach to Optically Active Cyclohexenones

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2006 Dec 1

PMID 17136250

Citations 11

Authors

Armando Carlone

Mauro Marigo

Chris North

Aitor Landa

Karl Anker Jorgensen

Affiliations

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Abstract

Optically active 2,5-disubstituted-cyclohexen-2-one derivatives have been prepared in a one-pot process consisting of five reaction steps: an organocatalytic asymmetric conjugated addition of beta-ketoesters to alpha,beta-unsaturated aldehydes that proceeds in aqueous solutions or under solvent-free conditions has been implemented in a multi-step process.

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