Aph(3')-IIc, an Aminoglycoside Resistance Determinant from Stenotrophomonas Maltophilia

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2006 Nov 8

PMID 17088477

Citations 42

Authors

Aki Okazaki

Matthew B Avison

Affiliations

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Abstract

We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.

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