Next-generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits

Overview

Journal J Neurosci

Specialty Neurology

Date 2006 Oct 13

PMID 17035522

Citations 284

Authors

Karl Deisseroth

Guoping Feng

Ania K Majewska

Gero Miesenbock

Alice Ting

Mark J Schnitzer

Affiliations

Soon will be listed here.

Abstract

Emerging technologies from optics, genetics, and bioengineering are being combined for studies of intact neural circuits. The rapid progression of such interdisciplinary "optogenetic" approaches has expanded capabilities for optical imaging and genetic targeting of specific cell types. Here we explore key recent advances that unite optical and genetic approaches, focusing on promising techniques that either allow novel studies of neural dynamics and behavior or provide fresh perspectives on classic model systems.

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