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Identification of a Novel Boron-containing Antibacterial Agent (AN0128) with Anti-inflammatory Activity, for the Potential Treatment of Cutaneous Diseases

Overview
Specialty Biochemistry
Date 2006 Sep 26
PMID 16997550
Citations 16
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Abstract

A series of borinic acid picolinate esters were synthesized and screened for their minimum inhibitory concentration (MIC) against Gram-positive and -negative bacteria. Our lead compounds were then screened for anti-inflammatory activity. From these studies, we identified 3-hydroxypyridine-2-carbonyloxy-bis(3-chloro-4-methylphenyl)borane (2g, AN0128) as having the best combination of anti-bacterial and anti-inflammatory activities. This compound is now in clinical development for dermatological conditions.

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