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Risk Factors for Isolation of Strains Susceptible Only to Polymyxin Among Patients with Pseudomonas Aeruginosa Bacteremia

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 2006 Jun 28
PMID 16801440
Citations 8
Authors
Matthew E Falagas
Patra K Koletsi
Petros Kopterides
Argyris Michalopoulos
Affiliations
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Abstract

We conducted a case-control study to identify risk factors associated with the isolation of Pseudomonas aeruginosa strains susceptible only to polymyxin from blood by comparing data between 16 patients with blood isolates that were susceptible only to polymyxins and 40 patients with blood isolates that were susceptible to carbapenems. The multivariable analysis showed that exposure to carbapenems was associated with the development of P. aeruginosa bacteremia susceptible only to polymyxin (odds ratio, 9.0; 95% confidence interval, 2.4 to 34.3; P = 0.001).

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References
1.
Harris A, Karchmer T, Carmeli Y, Samore M . Methodological principles of case-control studies that analyzed risk factors for antibiotic resistance: a systematic review. Clin Infect Dis. 2001; 32(7):1055-61. DOI: 10.1086/319600. View
2.
Poole K . Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J Mol Microbiol Biotechnol. 2001; 3(2):255-64. View
3.
Harris A, Samore M, Lipsitch M, Kaye K, Perencevich E, Carmeli Y . Control-group selection importance in studies of antimicrobial resistance: examples applied to Pseudomonas aeruginosa, Enterococci, and Escherichia coli. Clin Infect Dis. 2002; 34(12):1558-63. DOI: 10.1086/340533. View
4.
Gaynes R, Edwards J . Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis. 2005; 41(6):848-54. DOI: 10.1086/432803. View
5.
Bratu S, Quale J, Cebular S, Heddurshetti R, Landman D . Multidrug-resistant Pseudomonas aeruginosa in Brooklyn, New York: molecular epidemiology and in vitro activity of polymyxin B. Eur J Clin Microbiol Infect Dis. 2005; 24(3):196-201. DOI: 10.1007/s10096-005-1294-x. View