Extended Longevity of Wild-derived Mice is Associated with Peroxidation-resistant Membranes

Overview

Journal Mech Ageing Dev

Specialty Geriatrics

Date 2006 Apr 20

PMID 16620917

Citations 31

Authors

A J Hulbert

Sally C Faulks

James M Harper

Richard A Miller

Rochelle Buffenstein

Affiliations

Soon will be listed here.

Abstract

Two lines of mice, Idaho (Id) and Majuro (Ma), both derived from wild-trapped progenitors, have previously been shown to have extended lifespans in captivity when compared to a genetically heterogenous laboratory line of mice (DC). We have examined whether membrane fatty composition varies with lifespan within the species Mus musculus in a similar manner to that previously demonstrated between mammal species. Muscle and liver phospholipids from these long-living mice lines have a reduced amount of the highly polyunsaturated omega-3 docosahexaenoic acid compared to the DC mice, and consequently their membranes are less likely to peroxidative damage. The relationship between maximum longevity and membrane peroxidation index is similar for these mice lines as previously observed for mammals in general. It is suggested that peroxidation-resistant membranes may be an important component of extended longevity.

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