Membrane Fatty Acid Composition of Tissues is Related to Body Mass of Mammals

Overview

Journal J Membr Biol

Date 1995 Nov 1

PMID 8558599

Citations 21

Authors

P Couture

A J Hulbert

Affiliations

Soon will be listed here.

Abstract

Phospholipids were extracted from tissues (heart, skeletal muscle, kidney cortex, liver and brain) of mammals representing a 9,000-fold range in body mass (mouse, rat, rabbit, sheep and cattle) and their fatty acid composition was determined. In heart, skeletal muscle and kidney cortex, there were significant allometric decreases in the Unsaturation Index (UI; average number of double bonds per 100 fatty acid molecules) with increasing body mass. There were significant inverse allometric relationships between body mass and the proportion of docosahexaenoic acid (22:6 omega 3) in heart and skeletal muscle. In heart, skeletal muscle and kidney cortex, larger mammals also had shorter fatty acid chains in their phospholipids and a higher proportion of monounsaturates. In liver, smaller mammals had a higher UI than larger mammals (except the rabbit, which had the lowest UI and very low proportions of omega 3 fatty acids). The brain of all mammals maintained a high UI with similar levels of polyunsaturated fatty acids, especially 22:6 omega 3. Our results suggest that in heart, skeletal muscle and kidney cortex the activity of the elongases and desaturases are reduced in large mammals compared to small mammals. The allometric trends in membrane composition may be involved in modifying membrane permeability. It is proposed that the elevated degree of polyunsaturation in the membranes of several tissues from small mammals is related to their higher metabolic activity.

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References

de Gier J, Mandersloot J, Van Deenen L . Lipid composition and permeability of liposomes. Biochim Biophys Acta. 1968; 150(4):666-75. DOI: 10.1016/0005-2736(68)90056-4. View

Fettiplace R, Haydon D . Water permeability of lipid membranes. Physiol Rev. 1980; 60(2):510-50. DOI: 10.1152/physrev.1980.60.2.510. View

Charnock J, Abeywardena M, Poletti V, McLennan P . Differences in fatty acid composition of various tissues of the marmoset monkey (Callithrix jacchus) after different lipid supplemented diets. Comp Biochem Physiol Comp Physiol. 1992; 101(2):387-93. DOI: 10.1016/0300-9629(92)90551-z. View

Spector A, Yorek M . Membrane lipid composition and cellular function. J Lipid Res. 1985; 26(9):1015-35. View

Hazel J . Effects of temperature on the structure and metabolism of cell membranes in fish. Am J Physiol. 1984; 246(4 Pt 2):R460-70. DOI: 10.1152/ajpregu.1984.246.4.R460. View

Brand M, Couture P, Else P, Withers K, Hulbert A . Evolution of energy metabolism. Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile. Biochem J. 1991; 275 ( Pt 1):81-6. PMC: 1150016. DOI: 10.1042/bj2750081. View

Wiley J, Cooper R . Inhibition of cation cotransport by cholesterol enrichment of human red cell membranes. Biochim Biophys Acta. 1975; 413(3):425-31. DOI: 10.1016/0005-2736(75)90125-x. View

Papahadjopoulos D, Jacobson K, Nir S, Isac T . Phase transitions in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol. Biochim Biophys Acta. 1973; 311(3):330-48. DOI: 10.1016/0005-2736(73)90314-3. View

Ehringer W, Belcher D, Wassall S, Stillwell W . A comparison of the effects of linolenic (18:3 omega 3) and docosahexaenoic (22:6 omega 3) acids on phospholipid bilayers. Chem Phys Lipids. 1990; 54(2):79-88. DOI: 10.1016/0009-3084(90)90063-w. View

10.

Hoch F . Cardiolipins and biomembrane function. Biochim Biophys Acta. 1992; 1113(1):71-133. DOI: 10.1016/0304-4157(92)90035-9. View

11.

Jenski L, Sturdevant L, Ehringer W, Stillwell W . Omega 3 fatty acids increase spontaneous release of cytosolic components from tumor cells. Lipids. 1991; 26(5):353-8. DOI: 10.1007/BF02537198. View

12.

Porter R, Brand M . Body mass dependence of H+ leak in mitochondria and its relevance to metabolic rate. Nature. 1993; 362(6421):628-30. DOI: 10.1038/362628a0. View

13.

Couture P, Hulbert A . Relationship between body mass, tissue metabolic rate, and sodium pump activity in mammalian liver and kidney. Am J Physiol. 1995; 268(3 Pt 2):R641-50. DOI: 10.1152/ajpregu.1995.268.3.R641. View

14.

Kimelberg H . Alterations in phospholipid-dependent (Na+ +K+)-ATPase activity due to lipid fluidity. Effects of cholesterol and Mg2+. Biochim Biophys Acta. 1975; 413(1):143-56. DOI: 10.1016/0005-2736(75)90065-6. View

15.

Stubbs C, Smith A . The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim Biophys Acta. 1984; 779(1):89-137. DOI: 10.1016/0304-4157(84)90005-4. View

16.

Hulbert A, Else P . Evolution of mammalian endothermic metabolism: mitochondrial activity and cell composition. Am J Physiol. 1989; 256(1 Pt 2):R63-9. DOI: 10.1152/ajpregu.1989.256.1.R63. View

17.

Stillwell W, Ehringer W, Jenski L . Docosahexaenoic acid increases permeability of lipid vesicles and tumor cells. Lipids. 1993; 28(2):103-8. DOI: 10.1007/BF02535772. View

18.

GUDBJARNASON S . Dynamics of n-3 and n-6 fatty acids in phospholipids of heart muscle. J Intern Med Suppl. 1989; 731:117-28. DOI: 10.1111/j.1365-2796.1989.tb01445.x. View

19.

Lee A . Lipids and their effects on membrane proteins: evidence against a role for fluidity. Prog Lipid Res. 1991; 30(4):323-48. DOI: 10.1016/0163-7827(91)90002-m. View

20.

White F, Somero G . Acid-base regulation and phospholipid adaptations to temperature: time courses and physiological significance of modifying the milieu for protein function. Physiol Rev. 1982; 62(1):40-90. DOI: 10.1152/physrev.1982.62.1.40. View