A Critical Role for Dorsal Progenitors in Cortical Myelination

Overview

Journal J Neurosci

Specialty Neurology

Date 2006 Jan 27

PMID 16436615

Citations 54

Authors

Tao Yue

Kendy Xian

Edward Hurlock

Mei Xin

Steven G Kernie

Luis F Parada

Q Richard Lu

Affiliations

Soon will be listed here.

Abstract

Much controversy regarding the anatomical sources of oligodendrocytes in the spinal cord and hindbrain has been resolved. However, the relative contribution of dorsal and ventral progenitors to myelination of the cortex is still a subject of debate. To assess the contribution of dorsal progenitors to cortical myelination, we ablated the basic helix-loop-helix transcription factor Olig2 in the developing dorsal telencephalon. In Olig2-ablated cortices, myelination is arrested at the progenitor stage. Under these conditions, ventrally derived oligodendrocytes migrate dorsally into the Olig2-ablated territory but cannot fully compensate for myelination deficits observed at postnatal stages. Thus, spatially restricted ablation of Olig2 function unmasks a contribution of dorsal progenitors to cortical myelination that is much greater than hitherto appreciated.

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