Q Richard Lu
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Explore the profile of Q Richard Lu including associated specialties, affiliations and a list of published articles.
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Articles
133
Citations
5833
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Recent Articles
1.
Li C, Xie Q, Ghosh S, Cao B, Du Y, Vo G, et al.
JCI Insight
. 2025 Mar;
10(5).
PMID: 40059829
Glioblastoma (GBM) is the most lethal brain cancer, with GBM stem cells (GSCs) driving therapeutic resistance and recurrence. Targeting GSCs offers a promising strategy for preventing tumor relapse and improving...
2.
Kiang K, Wong Y, Sengupta S, Roussel M, Lu Q
Annu Rev Neurosci
. 2025 Feb;
PMID: 39952636
Medulloblastoma is the most common pediatric brain cancer and is broadly categorized into four molecular subgroups. Understanding the cell origins of medulloblastoma is crucial for preventing tumor formation and relapse....
3.
Myers B, Brayer K, Paez-Beltran L, Villicana E, Keith M, Suzuki H, et al.
Nat Commun
. 2024 Nov;
15(1):10363.
PMID: 39609428
Glioblastomas (GBMs) are highly aggressive, infiltrative, and heterogeneous brain tumors driven by complex genetic alterations. The basic-helix-loop-helix (bHLH) transcription factors ASCL1 and OLIG2 are dynamically co-expressed in GBMs; however, their...
4.
Correction: STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia
Weng Q, Zhao M, Zheng J, Yang L, Xu Z, Zhang Z, et al.
Cell Death Differ
. 2024 Nov;
32(2):369.
PMID: 39511405
No abstract available.
5.
Liu K, Kang Z, Yang M, Chen F, Xia M, Dai W, et al.
Glia
. 2024 Oct;
73(1):140-158.
PMID: 39392208
Brain vasculature formation begins with vessel invasion from the perineural vascular plexus, which expands through vessel sprouting and growth. Recent studies have indicated the existence of oligodendrocyte-vascular crosstalk during development....
6.
Huang G, Li Z, Liu X, Guan M, Zhou S, Zhong X, et al.
Nat Neurosci
. 2024 Sep;
27(11):2261.
PMID: 39317798
No abstract available.
7.
Huang G, Li Z, Liu X, Guan M, Zhou S, Zhong X, et al.
Nat Neurosci
. 2024 Sep;
27(11):2073-2085.
PMID: 39266660
The decreased ability of mature oligodendrocytes to produce myelin negatively affects remyelination in demyelinating diseases and aging, but the underlying mechanisms are incompletely understood. In the present study, we identify...
8.
Cui S, Chen T, Xin D, Chen F, Zhong X, Dong C, et al.
J Neurosci
. 2024 Aug;
44(39).
PMID: 39151953
Oligodendrocyte myelination and remyelination after injury are intricately regulated by various intrinsic and extrinsic factors, including transcriptional regulators. Among these, the zinc-finger protein ZFP488 is an oligodendrocyte-enriched transcriptional regulator that...
9.
Huynh N, Osipovitch M, Foti R, Bates J, Mansky B, Cano J, et al.
Brain
. 2024 Jul;
147(9):3099-3112.
PMID: 39028640
Huntington's disease and juvenile-onset schizophrenia have long been regarded as distinct disorders. However, both manifest cell-intrinsic abnormalities in glial differentiation, with resultant astrocytic dysfunction and hypomyelination. To assess whether a...
10.
Kiang K, Ahad L, Zhong X, Lu Q
Trends Cell Biol
. 2024 May;
34(7):566-577.
PMID: 38806345
Biomolecular condensates, the membraneless cellular compartments formed by liquid-liquid phase separation (LLPS), represent an important mechanism for physiological and tumorigenic processes. Recent studies have advanced our understanding of how these...