Fanconi Anemia (cross)linked to DNA Repair

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2005 Dec 27

PMID 16377561

Citations 146

Authors

Laura J Niedernhofer

Astrid S Lalai

Jan H J Hoeijmakers

Affiliations

Soon will be listed here.

Abstract

Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.

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