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Clinical Progression of Methicillin-resistant Staphylococcus Aureus Vertebral Osteomyelitis Associated with Reduced Susceptibility to Daptomycin

Overview
Journal J Clin Microbiol
Specialty Microbiology
Date 2005 Oct 7
PMID 16208025
Citations 20
Authors
Holenarasipur R Vikram
Nancy L Havill
Laura M Koeth
John M Boyce
Affiliations
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Abstract

Daptomycin, a novel cyclic lipopeptide antibiotic, exhibits rapid bactericidal activity in vitro against most clinically relevant gram-positive organisms, including drug-resistant pathogens. Herein we describe a patient in whom methicillin-resistant Staphylococcus aureus with reduced susceptibility to daptomycin was responsible for bacteremia and progressive vertebral osteomyelitis during daptomycin therapy.

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References
1.
Fuchs P, Barry A, Brown S . Daptomycin susceptibility tests: interpretive criteria, quality control, and effect of calcium on in vitro tests. Diagn Microbiol Infect Dis. 2000; 38(1):51-8. DOI: 10.1016/s0732-8893(00)00164-4. View
2.
Sakoulas G, Eliopoulos G, Alder J, Eliopoulos C . Efficacy of daptomycin in experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003; 47(5):1714-8. PMC: 153308. DOI: 10.1128/AAC.47.5.1714-1718.2003. View
3.
Fiebelkorn K, Crawford S, McElmeel M, Jorgensen J . Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci. J Clin Microbiol. 2003; 41(10):4740-4. PMC: 254362. DOI: 10.1128/JCM.41.10.4740-4744.2003. View
4.
Jevitt L, Smith A, Williams P, Raney P, McGowan Jr J, Tenover F . In vitro activities of Daptomycin, Linezolid, and Quinupristin-Dalfopristin against a challenge panel of Staphylococci and Enterococci, including vancomycin-intermediate staphylococcus aureus and vancomycin-resistant Enterococcus faecium. Microb Drug Resist. 2004; 9(4):389-93. DOI: 10.1089/107662903322762833. View
5.
Mangili A, Bica I, Snydman D, Hamer D . Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis. 2005; 40(7):1058-60. DOI: 10.1086/428616. View