Developmental Regulation of Foxp3 Expression During Ontogeny

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2005 Oct 6

PMID 16203863

Citations 199

Authors

Jason D Fontenot

James L Dooley

Andrew G Farr

Alexander Y Rudensky

Affiliations

Soon will be listed here.

Abstract

Thymectomy of neonatal mice can result in the development of autoimmune pathology. It has been proposed that thymic output of regulatory T (T reg) cells is delayed during ontogeny and that the development of autoimmune disease in neonatally thymectomized mice is caused by the escape of self-reactive T cells before thymectomy without accompanying T reg cells. However, the kinetics of T reg cell production within the thymus during ontogeny has not been assessed. We demonstrate that the development of Foxp3-expressing T reg cells is substantially delayed relative to nonregulatory thymocytes during ontogeny. Based on our data, we speculate that induction of Foxp3 in developing thymocytes and, thus, commitment to the T reg cell lineage is facilitated by a signal largely associated with the thymic medulla.

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