Andrew G Farr
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Explore the profile of Andrew G Farr including associated specialties, affiliations and a list of published articles.
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33
Citations
2826
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Recent Articles
1.
Jordan-Williams K, Ramanujam N, Farr A, Ruddell A
PLoS One
. 2016 May;
11(5):e0156079.
PMID: 27224029
Lymphocyte- and leukocyte-mediated lymph node (LN) lymphatic sinus growth (lymphangiogenesis) is involved in immune responses and in diseases including cancer and arthritis. We previously discovered a 10.1.1 Ab that recognizes...
2.
Furuya M, Kirschbaum S, Paulovich A, Pauli B, Zhang H, Alexander J, et al.
J Immunol
. 2010 Oct;
185(10):5769-77.
PMID: 20937843
The lymphatic circulation mediates drainage of fluid and cells from the periphery through lymph nodes, facilitating immune detection of lymph-borne foreign Ags. The 10.1.1 mAb recognizes a lymphatic endothelial Ag,...
3.
Cohen J, Guidi C, Tewalt E, Qiao H, Rouhani S, Ruddell A, et al.
J Exp Med
. 2010 Mar;
207(4):681-8.
PMID: 20308365
Peripheral immune tolerance is generally thought to result from cross-presentation of tissue-derived proteins by quiescent tissue-resident dendritic cells to self-reactive T cells that have escaped thymic negative selection, leading to...
4.
Dumortier A, Durham A, Di Piazza M, Vauclair S, Koch U, Ferrand G, et al.
PLoS One
. 2010 Feb;
5(2):e9258.
PMID: 20174635
Background: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied...
5.
Mazzucchelli R, Warming S, Lawrence S, Ishii M, Abshari M, Washington A, et al.
PLoS One
. 2009 Nov;
4(11):e7637.
PMID: 19907640
Interleukin-7 (IL-7) is required for lymphocyte development and homeostasis although the actual sites of IL-7 production have never been clearly identified. We produced a bacterial artificial chromosome (BAC) transgenic mouse...
6.
Dooley J, Erickson M, Farr A
J Immunol
. 2009 Sep;
183(8):5042-9.
PMID: 19786540
Modeling of thymic epithelial differentiation has been guided by several important underlying assumptions. One is that within epithelial tissues derived from pharyngeal endoderm, FoxN1 expression is signature for the thymic...
7.
Dooley J, Erickson M, Farr A
J Immunol
. 2008 Oct;
181(8):5225-32.
PMID: 18832676
A widely held model of thymic epithelial differentiation is based on patterns of keratin expression, where a K8(+)K5(+) progenitor gives rise to K8(+)K5/K14(-) cortical thymic epithelium (CTEC), and medullary thymic...
8.
Liston A, Nutsch K, Farr A, Lund J, Rasmussen J, Koni P, et al.
Proc Natl Acad Sci U S A
. 2008 Aug;
105(33):11903-8.
PMID: 18695219
Regulatory Foxp3(+) T cells (T(R)) are indispensable for preventing autoimmune pathology in multiple organs and tissues. During thymic differentiation T cell receptor (TCR)-ligand interactions within a certain increased affinity range,...
9.
Demehri S, Liu Z, Lee J, Lin M, Crosby S, Roberts C, et al.
PLoS Biol
. 2008 May;
6(5):e123.
PMID: 18507503
Epidermal keratinocytes form a highly organized stratified epithelium and sustain a competent barrier function together with dermal and hematopoietic cells. The Notch signaling pathway is a critical regulator of epidermal...
10.
Sokol C, Barton G, Farr A, Medzhitov R
Nat Immunol
. 2008 Feb;
9(3):310-8.
PMID: 18300366
Both metazoan parasites and simple protein allergens induce T helper type 2 (TH2) immune responses, but the mechanisms by which the innate immune system senses these stimuli are unknown. In...