Quantitative Heel Ultrasound in a Population-based Study in Italy and Its Relationship with Fracture History: the ESOPO Study

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2005 Sep 6

PMID 16142503

Citations 42

Authors

S Maggi

M Noale

S Giannini

S Adami

D Defeo

G Isaia

L Sinigaglia

P Filipponi

G Crepaldi

Affiliations

Soon will be listed here.

Abstract

We assessed the clinical usefulness of quantitative ultrasound (QUS) in defining the prevalence rates of osteoporosis and osteopenia and their association with fractures of the forearm, vertebrae, and hip. The ESOPO study was conducted in 2001 and assessed a random sample of 11,011 women and 4,981 men, in 83 centers spread all over Italy. A large array of risk factors was investigated, and self-reported history of fractures was collected in a questionnaire. After the patient had undergone interview and a brief physical examination, QUS of the heel was performed, using the Achilles apparatus (GE-Lunar, Madison, USA). The prevalence rate of osteoporosis in women 40-79 years old was approximately 18.5%, while the rate of osteopenia was about 44.7%; in men 60-79 years of age the rates were 10% and 36%, respectively. A strong association with fractures was found for osteoporosis and osteopenia in both men and women, independently of all traditional risk factors, including age. These results confirm the suitability of US measurements as a tool for detecting individuals at risk of fractures.

Citing Articles

Determination of the Combined Effects of Asian Herbal Medicine with Calcium and/or Vitamin D Supplements on Bone Mineral Density in Primary Osteoporosis: A Systematic Review and Meta-Analysis.

Park H, Kim M, Yoo Y, Lee B, Choi Y, Son C Osteoporos Int. 2024; 35(7):1-21.

PMID: 38472336 PMC: 11652406. DOI: 10.1007/s00198-024-07061-0.

Assessment of the Quality of Life of Women after Osteoporotic Vertebral Fracture with Consideration of Socio-Demographic Characteristics and Selected Factors Concerning the State of Health.

Dziedzic M, Janiszewska M, Gozdziewska M, Kowalska W, Rolinski J Int J Environ Res Public Health. 2022; 19(19).

PMID: 36231538 PMC: 9566652. DOI: 10.3390/ijerph191912237.

Quantitative Ultrasound (QUS) in the Management of Osteoporosis and Assessment of Fracture Risk: An Update.

Hans D, Metrailler A, Rodriguez E, Lamy O, Shevroja E Adv Exp Med Biol. 2022; 1364:7-34.

PMID: 35508869 DOI: 10.1007/978-3-030-91979-5_2.

Association of Serum Periostin Level with Classical Bone Turnover Markers and Bone Mineral Density in Shanghai Chinese Postmenopausal Women with Osteoporosis.

Li R, Zhu X, Zhang M, Zong G, Zhang K Int J Gen Med. 2021; 14:7639-7646.

PMID: 34764677 PMC: 8574128. DOI: 10.2147/IJGM.S335296.

Association between quantitative bone ultrasound and self-reported physical activity in nursing homes residents.

Cvijetic S, Kovacic J Eur Geriatr Med. 2021; 10(4):659-666.

PMID: 34652728 DOI: 10.1007/s41999-019-00183-3.

References

Gehlbach S, Bigelow C, Heimisdottir M, May S, Walker M, Kirkwood J . Recognition of vertebral fracture in a clinical setting. Osteoporos Int. 2000; 11(7):577-82. DOI: 10.1007/s001980070078. View

Wehbe J, Cortbaoui C, Chidiac R, Nehme A, Melki R, Bedran F . Age-associated changes in quantitative ultrasonometry (QUS) of the os calcis in Lebanese women-assessment of a Lebanese reference population. J Musculoskelet Neuronal Interact. 2005; 3(3):232-9. View

Varenna M, Binelli L, Zucchi F, Rossi V, Sinigaglia L . Prevalence of osteoporosis and fractures in a migrant population from southern to northern Italy: a cross-sectional, comparative study. Osteoporos Int. 2003; 14(9):734-40. DOI: 10.1007/s00198-003-1438-8. View

Ballard P, Purdie D, Langton C, Steel S, Mussurakis S . Prevalence of osteoporosis and related risk factors in UK women in the seventh decade: osteoporosis case finding by clinical referral criteria or predictive model?. Osteoporos Int. 1999; 8(6):535-9. DOI: 10.1007/s001980050095. View

Hans D, Arlot M, Schott A, Roux J, Kotzki P, Meunier P . Do ultrasound measurements on the os calcis reflect more the bone microarchitecture than the bone mass?: a two-dimensional histomorphometric study. Bone. 1995; 16(3):295-300. DOI: 10.1016/8756-3282(94)00041-7. View

Binkley N, Kiebzak G, Lewiecki E, Krueger D, Gangnon R, Miller P . Recalculation of the NHANES database SD improves T-score agreement and reduces osteoporosis prevalence. J Bone Miner Res. 2005; 20(2):195-201. DOI: 10.1359/JBMR.041115. View

Gluer C, Eastell R, Reid D, Felsenberg D, Roux C, Barkmann R . Association of five quantitative ultrasound devices and bone densitometry with osteoporotic vertebral fractures in a population-based sample: the OPUS Study. J Bone Miner Res. 2004; 19(5):782-93. DOI: 10.1359/JBMR.040304. View

Turner C, Eich M . Ultrasonic velocity as a predictor of strength in bovine cancellous bone. Calcif Tissue Int. 1991; 49(2):116-9. DOI: 10.1007/BF02565132. View

Tenenhouse A, Joseph L, Kreiger N, Poliquin S, Murray T, Blondeau L . Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int. 2001; 11(10):897-904. DOI: 10.1007/s001980070050. View

10.

Bush T, Miller S, GOLDEN A, Hale W . Self-report and medical record report agreement of selected medical conditions in the elderly. Am J Public Health. 1989; 79(11):1554-6. PMC: 1349815. DOI: 10.2105/ajph.79.11.1554. View

11.

Boyanov M, Popivanov P . Prevalence of low forearm bone density in a Bulgarian female referral population. Osteoporos Int. 2002; 13(4):288-95. DOI: 10.1007/s001980200028. View

12.

. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994; 843:1-129. View

13.

Naves M, Diaz-Lopez J, Gomez C, Rodriguez-Rebollar A, Serrano-Arias M, Cannata-Andia J . Prevalence of osteoporosis in men and determinants of changes in bone mass in a non-selected Spanish population. Osteoporos Int. 2004; 16(6):603-9. DOI: 10.1007/s00198-004-1727-x. View

14.

Weiss M, Hagag P, Rapoport M . Reference database for bone speed of sound measurement by a novel quantitative multi-site ultrasound device. Osteoporos Int. 2000; 11(8):688-96. DOI: 10.1007/s001980070067. View

15.

Nicholson P, Haddaway M, Davie M . The dependence of ultrasonic properties on orientation in human vertebral bone. Phys Med Biol. 1994; 39(6):1013-24. DOI: 10.1088/0031-9155/39/6/007. View

16.

Shilbayeh S . Prevalence of osteoporosis and its reproductive risk factors among Jordanian women: a cross-sectional study. Osteoporos Int. 2003; 14(11):929-40. DOI: 10.1007/s00198-003-1458-4. View

17.

Gluer C, Wu C, Jergas M, Goldstein S, Genant H . Three quantitative ultrasound parameters reflect bone structure. Calcif Tissue Int. 1994; 55(1):46-52. DOI: 10.1007/BF00310168. View

18.

Hans D, Dargent-Molina P, Schott A, Sebert J, Cormier C, Kotzki P . Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet. 1996; 348(9026):511-4. DOI: 10.1016/s0140-6736(95)11456-4. View

19.

Greenspan S, Cheng S, Miller P, Orwoll E . Clinical performance of a highly portable, scanning calcaneal ultrasonometer. Osteoporos Int. 2001; 12(5):391-8. DOI: 10.1007/s001980170108. View

20.

Lin J, Chen J, Chang H, Ho C . Evaluation of bone mineral density by quantitative ultrasound of bone in 16,862 subjects during routine health examination. Br J Radiol. 2001; 74(883):602-6. DOI: 10.1259/bjr.74.883.740602. View