Assessment of Myocardial Perfusion by Dynamic N-13 Ammonia PET Imaging: Comparison of 2 Tracer Kinetic Models

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 2005 Aug 9

PMID 16084429

Citations 9

Authors

Aliasghar Khorsand

Senta Graf

Christian Pirich

Otto Muzik

Kurt Kletter

Robert Dudczak

Gerald Maurer

Heinz Sochor

Ernst Schuster

Gerold Porenta

Affiliations

Soon will be listed here.

Abstract

Background: Measurement of myocardial blood flow (MBF) by dynamic nitrogen 13 ammonia (NH(3)) positron emission tomography (PET) uses tracer kinetic modeling to analyze time-activity curves. We compared 2 commonly used models with 2 compartments (2C) and 3 compartments (3C) for quantification of MBF and coronary flow reserve (CFR).

Methods And Results: Seventy-seven patients underwent NH(3) PET at rest and during hyperemia. Time-activity curves for blood pool and myocardial segments were obtained from short-axis images of dynamic sequences. Model fitting of the 2C and 3C models was performed to estimate regional MBF. MBF values calculated by 2C and 3C models were 0.98 +/- 0.31 mL.min(-1).g(-1) and 1.11 +/- 0.37 mL.min(-1).g(-1), respectively, at rest (P < .0001) and 2.79 +/- 1.18 mL.min(-1).g(-1) and 2.46 +/- 1.02 mL.min(-1).g(-1), respectively, during hyperemia (P < .01), resulting in a CFR of 3.02 +/- 1.31 and 2.39 +/- 1.15 (P < .0001), respectively. Significant correlation was observed between the 2 models for calculation of resting MBF (r = 0.78), hyperemic MBF (r = 0.68), and CFR (r = 0.68).

Conclusion: Measurements of MBF and CFR by 2C and 3C models are significantly related. However, quantification of MBF and CFR significantly differs between the methods. This difference needs to be considered when normal values are established or when measurements obtained with different methods need to be compared.

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