Nonhuman Primate Models of Asthma

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2005 Jun 22

PMID 15967818

Citations 24

Authors

Robert L Coffman

Edith M Hessel

Affiliations

Soon will be listed here.

Abstract

Asthma is a complex human disease that does not have an accurate counterpart in any common model organism. Most of our understanding of the immune mechanisms underlying asthma comes from studies in man and mouse. However, there are fundamental differences between the spontaneous disease in man and the experimentally induced counterparts in mice. We advocate more extensive use of nonhuman primate asthma models to reconcile these differences between man and mouse.

Citing Articles

Asthma: The Use of Animal Models and Their Translational Utility.

Woodrow J, Sheats M, Cooper B, Bayless R Cells. 2023; 12(7).

PMID: 37048164 PMC: 10093022. DOI: 10.3390/cells12071091.

A Novel Nonhuman Primate Model of Nonatopic Asthma.

Royer C, Miller L, Haczku A Methods Mol Biol. 2022; 2506:83-94.

PMID: 35771465 PMC: 11069454. DOI: 10.1007/978-1-0716-2364-0_6.

Targeting the OXE receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primates.

Cossette C, Miller L, Ye Q, Chourey S, Reddy C, Rokach J Br J Pharmacol. 2021; 179(2):322-336.

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G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action.

Wendell S, Fan H, Zhang C Pharmacol Rev. 2019; 72(1):1-49.

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Asthma in an Adult Female Vervet Monkey (Chlorocebus sabaeus).

Koster L, Simon B, Rawlins G, Beierschmitt A Comp Med. 2016; 66(1):68-72.

PMID: 26884413 PMC: 4752039.

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