Synthesis and Photochemotherapeutic Activity of Thiopyrano[2,3-e]indol-2-ones

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2005 Apr 20

PMID 15837311

Citations 4

Authors

Paola Barraja

Laura Sciabica

Patrizia Diana

Antonino Lauria

Alessandra Montalbano

Anna Maria Almerico

Gaetano Dattolo

Girolamo Cirrincione

Silvia Disaro

Giuseppe Basso

Giampietro Viola

Francesco DallAcqua

Affiliations

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Abstract

A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.

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