Genetic Causes of Human Heart Failure

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2005 Mar 15

PMID 15765133

Citations 103

Authors

Hiroyuki Morita

Jonathan Seidman

Christine E Seidman

Affiliations

Soon will be listed here.

Abstract

Factors that render patients with cardiovascular disease at high risk for heart failure remain incompletely defined. Recent insights into molecular genetic causes of myocardial diseases have highlighted the importance of single-gene defects in the pathogenesis of heart failure. Through analyses of the mechanisms by which a mutation selectively perturbs one component of cardiac physiology and triggers cell and molecular responses, studies of human gene mutations provide a window into the complex processes of cardiac remodeling and heart failure. Knowledge gleaned from these studies shows promise for defining novel therapeutic targets for genetic and acquired causes of heart failure.

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