Electrical Ventricular Remodeling in Dilated Cardiomyopathy

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2021 Oct 23

PMID 34685747

Citations 6

Authors

Christine Mages

Heike Gampp

Pascal Syren

Ann-Kathrin Rahm

Florian Andre

Norbert Frey

Patrick Lugenbiel

Dierk Thomas

Affiliations

Soon will be listed here.

Abstract

Ventricular arrhythmias contribute significantly to morbidity and mortality in patients with heart failure (HF). Pathomechanisms underlying arrhythmogenicity in patients with structural heart disease and impaired cardiac function include myocardial fibrosis and the remodeling of ion channels, affecting electrophysiologic properties of ventricular cardiomyocytes. The dysregulation of ion channel expression has been associated with cardiomyopathy and with the development of arrhythmias. However, the underlying molecular signaling pathways are increasingly recognized. This review summarizes clinical and cellular electrophysiologic characteristics observed in dilated cardiomyopathy (DCM) with ionic and structural alterations at the ventricular level. Furthermore, potential translational strategies and therapeutic options are highlighted.

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