Learning from Failure: Congestive Heart Failure in the Postgenomic Age

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2005 Mar 15

PMID 15765130

Citations 21

Authors

Ivor J Benjamin

Michael D Schneider

Affiliations

Soon will be listed here.

Abstract

The prognosis of heart failure is worse than that of most cancers, but new therapeutic interventions using stem and other cell-based therapies are succeeding in the fight against it, and old drugs, with new twists, are making a comeback. Genetically engineered animal models are driving insights into the molecular mechanisms that cause hearts to fail, accelerating drug discoveries, and inspiring cell-based therapeutic interventions for both acquired and inheritable cardiac diseases.

Citing Articles

Pomegranate peel extract protects against carbon tetrachloride-induced nephrotoxicity in mice through increasing antioxidants status.

Emam N, Anjum S, Okail H, Ibrahim M, Ahmad T Biomed Rep. 2020; 13(3):13.

PMID: 32765852 PMC: 7391291. DOI: 10.3892/br.2020.1320.

Cell shape determines gene expression: cardiomyocyte morphotypic transcriptomes.

Haftbaradaran Esfahani P, Elbeck Z, Sagasser S, Li X, Hossain M, Talukdar H Basic Res Cardiol. 2019; 115(1):7.

PMID: 31872302 PMC: 6928094. DOI: 10.1007/s00395-019-0765-7.

Velvet Antler Mobilizes Endothelial Progenitor Cells to Promote Angiogenesis and Repair Vascular Endothelial Injury in Rats Following Myocardial Infarction.

Li Y, Wang Z, Mao M, Zhao M, Xiao X, Sun W Front Physiol. 2019; 9:1940.

PMID: 30705637 PMC: 6344410. DOI: 10.3389/fphys.2018.01940.

Protective effects of curcumin and vitamin E on carbon tetrachloride-induced nephrotoxicity in rats.

Venkatanarayana G, Sudhakara G, Sivajyothi P, Indira P EXCLI J. 2016; 11:641-650.

PMID: 27847452 PMC: 5099890.

An experimental approach to study the function of mitochondria in cardiomyopathy.

Chung Y, Kang S BMB Rep. 2015; 48(10):541-8.

PMID: 26198095 PMC: 4911180. DOI: 10.5483/bmbrep.2015.48.10.153.

References

Singer J, Hill A, Burrage L, Olszens K, Song J, Justice M . Genetic dissection of complex traits with chromosome substitution strains of mice. Science. 2004; 304(5669):445-8. DOI: 10.1126/science.1093139. View

Skarnes W, von Melchner H, Wurst W, Hicks G, Nord A, Cox T . A public gene trap resource for mouse functional genomics. Nat Genet. 2004; 36(6):543-4. PMC: 2716026. DOI: 10.1038/ng0604-543. View

Small K, Mialet-Perez J, Seman C, Theiss C, Brown K, Liggett S . Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. Proc Natl Acad Sci U S A. 2004; 101(35):13020-5. PMC: 516511. DOI: 10.1073/pnas.0405074101. View

Ramirez-Bergeron D, Runge A, Cowden Dahl K, Fehling H, Keller G, Simon M . Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development. 2004; 131(18):4623-34. DOI: 10.1242/dev.01310. View

Bleumink G, Knetsch A, Sturkenboom M, Straus S, Hofman A, Deckers J . Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur Heart J. 2004; 25(18):1614-9. DOI: 10.1016/j.ehj.2004.06.038. View

Giaccia A, Simon M, Johnson R . The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev. 2004; 18(18):2183-94. PMC: 517513. DOI: 10.1101/gad.1243304. View

Liggett S . Genetically modified mouse models for pharmacogenomic research. Nat Rev Genet. 2004; 5(9):657-63. DOI: 10.1038/nrg1429. View

Xu X, Meiler S, Zhong T, Mohideen M, Crossley D, Burggren W . Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nat Genet. 2002; 30(2):205-9. DOI: 10.1038/ng816. View

Hoit B, Kiatchoosakun S, Restivo J, Kirkpatrick D, Olszens K, Shao H . Naturally occurring variation in cardiovascular traits among inbred mouse strains. Genomics. 2002; 79(5):679-85. DOI: 10.1006/geno.2002.6754. View

10.

Haghighi K, Kolokathis F, Pater L, Lynch R, Asahi M, Gramolini A . Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest. 2003; 111(6):869-76. PMC: 153772. DOI: 10.1172/JCI17892. View

11.

Jessup M, Brozena S . Heart failure. N Engl J Med. 2003; 348(20):2007-18. DOI: 10.1056/NEJMra021498. View

12.

Le Corvoisier P, Park H, Carlson K, Marchuk D, Rockman H . Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy. Hum Mol Genet. 2003; 12(23):3097-107. DOI: 10.1093/hmg/ddg333. View

13.

Kim Y, Park S, Balaban R, Nirenberg M, Kim Y . A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos. Proc Natl Acad Sci U S A. 2003; 101(1):159-64. PMC: 314155. DOI: 10.1073/pnas.0307205101. View

14.

Churchill G, Airey D, Allayee H, Angel J, Attie A, Beatty J . The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004; 36(11):1133-7. DOI: 10.1038/ng1104-1133. View

15.

Liew C, Dzau V . Molecular genetics and genomics of heart failure. Nat Rev Genet. 2004; 5(11):811-25. DOI: 10.1038/nrg1470. View

16.

Taylor A, Ziesche S, Yancy C, Carson P, DAgostino Jr R, Ferdinand K . Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004; 351(20):2049-57. DOI: 10.1056/NEJMoa042934. View

17.

Schneider M . Regenerative medicine: Prometheus unbound. Nature. 2004; 432(7016):451-3. DOI: 10.1038/432451a. View

18.

Bock-Marquette I, Saxena A, White M, DiMaio J, Srivastava D . Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004; 432(7016):466-72. DOI: 10.1038/nature03000. View

19.

Shapero M, Zhang J, Loraine A, Liu W, Di X, Liu G . MARA: a novel approach for highly multiplexed locus-specific SNP genotyping using high-density DNA oligonucleotide arrays. Nucleic Acids Res. 2004; 32(22):e181. PMC: 545476. DOI: 10.1093/nar/gnh178. View

20.

Hinds D, Seymour A, Durham L, Banerjee P, Ballinger D, Milos P . Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels. Hum Genomics. 2004; 1(6):421-34. PMC: 3500196. DOI: 10.1186/1479-7364-1-6-421. View