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Increased Structural Complexity Leads to Higher Activity: Peptides As Efficient and Versatile Catalysts for Asymmetric Aldol Reactions

Overview
Journal Org Lett
Specialties Biochemistry
Chemistry
Date 2005 Mar 12
PMID 15760149
Citations 19
Authors
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Abstract

[reaction: see text] Peptides containing a secondary amine and a carboxylic acid in a specific orientation to each other are presented as highly efficient catalysts for asymmetric aldol reactions: (1) their activity is considerably higher compared to that of proline, and (2) the enantioselectivity of the peptidic catalysts can be changed from (R)- to (S)-selectivity by simple modifications of the secondary structure.

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