Cell Therapy for Stroke

Overview

Journal NeuroRx

Specialty Neurology

Date 2005 Feb 18

PMID 15717044

Citations 25

Authors

Sean I Savitz

Jonathan H Dinsmore

Lawrence R Wechsler

Daniel M Rosenbaum

Louis R Caplan

Affiliations

Soon will be listed here.

Abstract

Increasing experimental evidence suggests that cell transplantation can enhance recovery from stroke in animal models of focal cerebral ischemia. Clinical trials have been investigating the effects of a human immortalized neuronal cell line and porcine fetal neurons in stroke victims with persistent and stable deficits. Preclinical studies are focusing on the effects of human stem cells from various sources including brain, bone marrow, umbilical cord, and adipose tissue. This review presents an overview of preclinical and clinical studies on cell therapy for stroke. We emphasize the current, limited knowledge about the biology of implant sources and discuss special conditions in stroke that will impact the potential success of neurotransplantation in clinical trials.

Citing Articles

Injectable biomaterial shuttles for cell therapy in stroke.

Samal J, Segura T Brain Res Bull. 2021; 176:25-42.

PMID: 34391821 PMC: 8524625. DOI: 10.1016/j.brainresbull.2021.08.002.

Holistic Approach of Swiss Fetal Progenitor Cell Banking: Optimizing Safe and Sustainable Substrates for Regenerative Medicine and Biotechnology.

Laurent A, Hirt-Burri N, Scaletta C, Michetti M, de Buys Roessingh A, Raffoul W Front Bioeng Biotechnol. 2020; 8:557758.

PMID: 33195124 PMC: 7644790. DOI: 10.3389/fbioe.2020.557758.

Genetic modification increases the survival and the neuroregenerative properties of transplanted neural stem cells.

Korshunova I, Rhein S, Garcia-Gonzalez D, Stolting I, Pfisterer U, Barta A JCI Insight. 2020; 5(4).

PMID: 31999645 PMC: 7101138. DOI: 10.1172/jci.insight.126268.

Cell-Based Therapies for Stroke: Are We There Yet?.

Krause M, Phan T, Ma H, Sobey C, Lim R Front Neurol. 2019; 10:656.

PMID: 31293500 PMC: 6603096. DOI: 10.3389/fneur.2019.00656.

Intracerebral transplantation of erythropoietin-producing fibroblasts facilitates neurogenesis and functional recovery in an ischemic stroke model.

Chou P, Tsai Y, Chen S, Tsai L, Chien C Brain Behav. 2019; 9(5):e01274.

PMID: 30920178 PMC: 6520520. DOI: 10.1002/brb3.1274.

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