Neural Stem Cell Transplantation for the Treatment of Primary Torsion Dystonia: A Case Report

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2016 Jul 23

PMID 27446258

Citations 1

Authors

Wen-Qing Ren

Feng Yin

Jian-Ning Zhang

Wang-Sheng Lu

Ying-Kui Liang

Josefin Adlerberth

Zeng-Min Tian

Affiliations

Soon will be listed here.

Abstract

Primary torsion dystonia (PTD) occurs due to a genetic mutation and often advances gradually. Currently, there is no therapy available that is able to inhibit progression. Neural stem cells (NSCs) are being investigated as potential therapies for neurodegenerative diseases, such as stroke and trauma. The present study evaluated the clinical effectiveness of NSC transplantation in an 18-year-old male patient with PTD, to assess the ability of this therapy to inhibit PTD progression. Genetic testing of the patient revealed a mutation in the torsion dystonia-1 () gene (907-909 delGAG). NSCs were bilaterally implanted in the globus pallidus of the patient through stereotactic surgery. Prior to surgery, the patient's Burke-Fahn-Marsden dystonia movement score (BFMDMS) was 21, which progressively decreased after surgery to 18, 17, 15 and 13 at 1, 2, 3 and 4 postoperative years, respectively. BFMDMS was improved by 38.1% over the 4 postoperative years. Although computed tomography and magnetic resonance imaging examinations showed no significant changes prior to and following surgery, postoperative brain positron emission tomography scans revealed increased glucose metabolism in the transplanted region. The clinical efficacy of NSC transplantation in this patient suggests its potential for the treatment of -positive patients with PTD.

Citing Articles

Clinical results of neurorestorative cell therapies and therapeutic indications according to cellular bio-proprieties.

Huang H, Sanberg P, Moviglia G, Sharma A, Chen L, Chen D Regen Ther. 2023; 23:52-59.

PMID: 37122360 PMC: 10130496. DOI: 10.1016/j.reth.2023.03.004.

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