Inflammation is Detrimental for Neurogenesis in Adult Brain

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2003 Oct 29

PMID 14581618

Citations 616

Authors

Christine T Ekdahl

Jan-Hendrik Claasen

Sara Bonde

Zaal Kokaia

Olle Lindvall

Affiliations

Soon will be listed here.

Abstract

New hippocampal neurons are continuously generated in the adult brain. Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats. The increased neurogenesis triggered by a brain insult is also attenuated if it is associated with microglia activation caused by tissue damage or lipopolysaccharide infusion. The impaired neurogenesis in inflammation is restored by systemic administration of minocycline, which inhibits microglia activation. Our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation.

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