Deregulated Estrogen Receptor Alpha Expression in Mammary Epithelial Cells of Transgenic Mice Results in the Development of Ductal Carcinoma in Situ

Overview

Journal Cancer Res

Specialty Oncology

Date 2005 Feb 12

PMID 15705859

Citations 53

Authors

M Silvina Frech

Ewa D Halama

Maddalena T Tilli

Baljit Singh

Edward J Gunther

Lewis A Chodosh

Jodi A Flaws

Priscilla A Furth

Affiliations

Soon will be listed here.

Abstract

A conditional tetracycline-responsive transgenic mouse model with deregulated estrogen receptor alpha expression in mammary epithelial cells developed ductal hyperplasia (DH), lobular hyperplasia, and ductal carcinoma in situ (DCIS) by 4 months of age. Higher proliferative rates were found in both normal and abnormal ductal and lobular structures. DH and DCIS but not normal ductal structures showed an increased percentage of cells with nuclear-localized cyclin D1. No differences in either the prevalence or extent of these phenotypes following exogenous 17beta-estradiol treatment were found suggesting that alteration of ERalpha expression was the rate-limiting factor in initiation of DH, lobular hyperplasia, and DCIS.

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