Edward J Gunther
Overview
Explore the profile of Edward J Gunther including associated specialties, affiliations and a list of published articles.
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17
Citations
853
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Recent Articles
1.
Linscott M, Ren J, Gestl S, Gunther E
Am J Pathol
. 2024 Mar;
194(7):1329-1345.
PMID: 38537934
A remote carcinogen exposure can predispose to breast cancer onset decades later, suggesting that carcinogen-induced mutations generate long-lived premalignant clones. How subsequent events influence the progression of specific premalignant clones...
2.
Li S, Gestl S, Gunther E
Cancer Prev Res (Phila)
. 2019 Nov;
13(2):173-184.
PMID: 31699706
Breast cancers evolve in a multistage process that can span decades after a carcinogenic exposure. It follows that long-lived precursor breast lesions persist in a subclinical state prior to completing...
3.
Keller R, Gunther E
Cell Rep
. 2019 Jan;
26(4):893-905.e4.
PMID: 30673612
Targeted cancer therapeutics select for drug-resistant rescue subclones (RSCs), which typically carry rescue mutations that restore oncogenic signaling. Whereas mutations underlying antibiotic resistance frequently burden drug-naive microbes with a fitness...
4.
Keller R, Gestl S, Lu A, Hoke A, Feith D, Gunther E
Carcinogenesis
. 2016 May;
37(8):810-816.
PMID: 27207659
Carcinogen exposures inscribe mutation patterns on cancer genomes and sometimes bias the acquisition of driver mutations toward preferred oncogenes, potentially dictating sensitivity to targeted agents. Whether and how carcinogen-specific mutation...
5.
Cleary A, Leonard T, Gestl S, Gunther E
Nature
. 2014 Apr;
508(7494):113-7.
PMID: 24695311
Cancer genome sequencing studies indicate that a single breast cancer typically harbours multiple genetically distinct subclones. As carcinogenesis involves a breakdown in the cell-cell cooperation that normally maintains epithelial tissue...
6.
Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth
Plichta K, Mathers J, Gestl S, Glick A, Gunther E
Cancer Res
. 2012 Sep;
72(22):5856-66.
PMID: 23010075
The mammary ducts of humans and mice are comprised of two main mammary epithelial cell (MEC) subtypes: a surrounding layer of basal MECs and an inner layer of luminal MECs....
7.
Jia W, Wang S, Horner J, Wang N, Wang H, Gunther E, et al.
FASEB J
. 2010 Dec;
25(3):979-89.
PMID: 21135040
Telomerase is tightly regulated in humans relative to mice, owing to the differential regulation of TERT genes. To explore hTERT regulation in vivo, we engineered mice with a 160-kb transgenic...
8.
McHenry P, Sears J, Herrick M, Chang P, Heckman-Stoddard B, Rybarczyk M, et al.
Breast Cancer Res
. 2010 Sep;
12(5):R73.
PMID: 20860838
Introduction: Rho GTPases are overexpressed and hyperactivated in human breast cancers. Deficiency of p190B RhoGAP, a major inhibitor of the Rho GTPases, inhibits mouse mammary tumor virus long terminal repeat...
9.
Shen Q, Uray I, Li Y, Zhang Y, Hill J, Xu X, et al.
Cancer Prev Res (Phila)
. 2009 Jan;
1(1):45-55.
PMID: 19138935
The oncogene erbB2 is overexpressed in 20% to 30% human breast cancers and is most commonly overexpressed in estrogen receptor (ER)-negative breast cancers. Transgenic mice expressing erbB2 develop ER-negative mammary...
10.
Debies M, Gestl S, Mathers J, Mikse O, Leonard T, Moody S, et al.
J Clin Invest
. 2007 Dec;
118(1):51-63.
PMID: 18060046
Breast cancers frequently progress or relapse during targeted therapy, but the molecular mechanisms that enable escape remain poorly understood. We elucidated genetic determinants underlying tumor escape in a transgenic mouse...