Focus on the Glycerophosphocholine Pathway in Choline Phospholipid Metabolism of Cancer

Overview

Journal NMR Biomed

Publisher Wiley

Date 2019 Jun 12

PMID 31184789

Citations 71

Authors

Kanchan Sonkar

Vinay Ayyappan

Caitlin M Tressler

Oluwatobi Adelaja

Ruoqing Cai

Menglin Cheng

Kristine Glunde

Affiliations

Soon will be listed here.

Abstract

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer-related studies have focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylcholine. Fewer and more recent studies have reported on the importance of glycerophosphocholine in cancer. In this review article, we summarize the recent literature on glycerophosphocholine metabolism with respect to its cancer biology and its detection by magnetic resonance spectroscopy applications.

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