Frat is Dispensable for Canonical Wnt Signaling in Mammals

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2005 Feb 1

PMID 15681612

Citations 23

Authors

Renee van Amerongen

Martijn Nawijn

Jonathan Franca-Koh

John Zevenhoven

Hanneke van der Gulden

Jos Jonkers

Anton Berns

Affiliations

Soon will be listed here.

Abstract

Wnt-signal transduction through beta-catenin is thought to require the inhibition of GSK3 by Frat/GBP. To investigate the role of Frat in mammalian development, we have generated mice with targeted mutations in all three murine Frat homologs. We show that Frat is normally expressed at sites of active Wnt signaling. Surprisingly, Frat-deficient mice do not display gross abnormalities. Moreover, canonical Wnt signaling in primary cells is unaffected by the loss of Frat. These studies show that Frat is not an essential component of the canonical Wnt pathway in higher organisms, despite the strict requirement of Frat/GBP for maternal Wnt signaling in Xenopus.

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