John Zevenhoven
Overview
Explore the profile of John Zevenhoven including associated specialties, affiliations and a list of published articles.
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21
Citations
2708
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Recent Articles
1.
Badhai J, Pandey G, Song J, Krijgsman O, Bhaskaran R, Chandrasekaran G, et al.
J Exp Med
. 2020 Apr;
217(6).
PMID: 32271879
We have generated mouse models of malignant mesothelioma (MM) based upon disruption of the Bap1, Nf2, and Cdkn2ab tumor suppressor loci in various combinations as also frequently observed in human...
2.
Wang L, Leite de Oliveira R, Huijberts S, Bosdriesz E, Pencheva N, Brunen D, et al.
Cell
. 2018 May;
173(6):1413-1425.e14.
PMID: 29754815
BRAF(V600E) mutant melanomas treated with inhibitors of the BRAF and MEK kinases almost invariably develop resistance that is frequently caused by reactivation of the mitogen activated protein kinase (MAPK) pathway....
3.
Melis M, Nevedomskaya E, van Burgsteden J, Cioni B, Van Zeeburg H, Song J, et al.
Oncotarget
. 2017 Dec;
8(55):93867-93877.
PMID: 29212195
Increasing evidence from epidemiological and pathological studies suggests a role of the immune system in the initiation and progression of multiple cancers, including prostate cancer. Reports on the contribution of...
4.
Semenova E, Kwon M, Monkhorst K, Song J, Bhaskaran R, Krijgsman O, et al.
Cell Rep
. 2016 Jul;
16(3):631-43.
PMID: 27373156
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor, and no effective treatment is available to date. Mouse models of SCLC based on the inactivation of Rb1 and Trp53...
5.
Kwon M, Proost N, Song J, Sutherland K, Zevenhoven J, Berns A
Genes Dev
. 2015 Jul;
29(15):1587-92.
PMID: 26215568
Tumor heterogeneity can create a unique symbiotic tumor microenvironment. Earlier, we showed that clonal evolution in mouse small cell lung cancer (SCLC) can result in subclones that, upon cografting, endow...
6.
Sutherland K, Song J, Kwon M, Proost N, Zevenhoven J, Berns A
Proc Natl Acad Sci U S A
. 2014 Mar;
111(13):4952-7.
PMID: 24586047
Much controversy surrounds the cell-of-origin of mutant K-Ras (K-RasG12D)-induced lung adenocarcinoma. To shed light on this issue, we have used technology that enables us to conditionally target K-RasG12D expression in...
7.
Desmet C, Gallenne T, Prieur A, Reyal F, Visser N, Wittner B, et al.
Proc Natl Acad Sci U S A
. 2013 Mar;
110(13):5139-44.
PMID: 23483055
Metastasis confronts clinicians with two major challenges: estimating the patient's risk of metastasis and identifying therapeutic targets. Because they are key signal integrators connecting cellular processes to clinical outcome, we...
8.
Westerman B, Blom M, Tanger E, van der Valk M, Song J, van Santen M, et al.
PLoS One
. 2012 May;
7(5):e35943.
PMID: 22574128
Bmi1 is a member of the polycomb repressive complex 1 and plays different roles during embryonic development, depending on the developmental context. Bmi1 over expression is observed in many types...
9.
Nacerddine K, Beaudry J, Ginjala V, Westerman B, Mattiroli F, Song J, et al.
J Clin Invest
. 2012 Apr;
122(5):1920-32.
PMID: 22505453
Prostate cancer (PCa) is a major lethal malignancy in men, but the molecular events and their interplay underlying prostate carcinogenesis remain poorly understood. Epigenetic events and the upregulation of polycomb...
10.
Krimpenfort P, Song J, Proost N, Zevenhoven J, Jonkers J, Berns A
Nature
. 2012 Feb;
482(7386):538-41.
PMID: 22358843
Since its discovery in the early 1990s the deleted in colorectal cancer (DCC) gene, located on chromosome 18q21, has been proposed as a tumour suppressor gene as its loss is...