Molecular Pathogenesis of Astrocytic Tumours

Overview

Journal J Neurooncol

Publisher Springer

Date 2005 Jan 28

PMID 15674475

Citations 36

Authors

Koichi Ichimura

Hiroko Ohgaki

Paul Kleihues

V Peter Collins

Affiliations

Soon will be listed here.

Abstract

Our current knowledge of the molecular pathogenesis of the diffuse adult astrocytic tumours is vast if compared to 20 years ago, yet we are far from understanding the details of this process at the molecular level and using such an understanding to logically and specifically treat patients' tumours. In other astrocytic tumours we have little or no knowledge of the molecular processes. This article will attempt to summarise the histological classification criteria and genetic data for all the astrocytic tumours. The current World Health Organisation classification lists six entities, some with subgroups. Common problems associated with the diagnosis of these tumours are outlined. While the molecular findings are not as yet used clinically, we are approaching a time when the histological investigation will have to be supplemented with molecular data to ensure the best choice of treatment for the patient and as an accurate indicator of prognosis.

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References

Mueller W, Mollenhauer J, Stockhammer F, Poustka A, von Deimling A . Rare mutations of the DMBT1 gene in human astrocytic gliomas. Oncogene. 2002; 21(38):5956-9. DOI: 10.1038/sj.onc.1205733. View

Listernick R, Charrow J, Gutmann D . Intracranial gliomas in neurofibromatosis type 1. Am J Med Genet. 1999; 89(1):38-44. DOI: 10.1002/(sici)1096-8628(19990326)89:1<38::aid-ajmg8>3.0.co;2-m. View

Humphrey P, Gangarosa L, Wong A, Archer G, Lund-Johansen M, Bjerkvig R . Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function. Biochem Biophys Res Commun. 1991; 178(3):1413-20. DOI: 10.1016/0006-291x(91)91051-d. View

Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker-Cummings C, Boneschi F . Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Nat Genet. 2002; 30(3):335-41. PMC: 2606053. DOI: 10.1038/ng832. View

van den Boom J, Wolter M, Kuick R, Misek D, Youkilis A, Wechsler D . Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. Am J Pathol. 2003; 163(3):1033-43. PMC: 1868272. DOI: 10.1016/S0002-9440(10)63463-3. View

Giannini C, Scheithauer B, Burger P, Brat D, Wollan P, Lach B . Pleomorphic xanthoastrocytoma: what do we really know about it?. Cancer. 1999; 85(9):2033-45. View

Galanis E, Buckner J, Kimmel D, Jenkins R, ALDERETE B, OFallon J . Gene amplification as a prognostic factor in primary and secondary high-grade malignant gliomas. Int J Oncol. 1998; 13(4):717-24. View

Liu L, Ichimura K, Pettersson E, Goike H, Collins V . The complexity of the 7p12 amplicon in human astrocytic gliomas: detailed mapping of 246 tumors. J Neuropathol Exp Neurol. 2001; 59(12):1087-93. DOI: 10.1093/jnen/59.12.1087. View

Sonoda Y, Murakami Y, Tominaga T, Kayama T, Yoshimoto T, Sekiya T . Deletion mapping of chromosome 10 in human glioma. Jpn J Cancer Res. 1996; 87(4):363-7. PMC: 5921111. DOI: 10.1111/j.1349-7006.1996.tb00231.x. View

10.

Libermann T, Nusbaum H, Razon N, Kris R, Lax I, Soreq H . Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature. 1985; 313(5998):144-7. DOI: 10.1038/313144a0. View

11.

Maccollin M, Mautner V . The diagnosis and management of neurofibromatosis 2 in childhood. Semin Pediatr Neurol. 1999; 5(4):243-52. DOI: 10.1016/s1071-9091(98)80003-x. View

12.

Kon H, Sonoda Y, Kumabe T, Yoshimoto T, Sekiya T, Murakami Y . Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas. Oncogene. 1998; 16(2):257-63. DOI: 10.1038/sj.onc.1201488. View

13.

Kropilak M, Jagelman D, Fazio V, Lavery I, McGannon E . Brain tumors in familial adenomatous polyposis. Dis Colon Rectum. 1989; 32(9):778-82. DOI: 10.1007/BF02562128. View

14.

Raffel C, Frederick L, OFallon J, Perry A, Jenkins R, James C . Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations. Clin Cancer Res. 2000; 5(12):4085-90. View

15.

Yamazaki H, Ohba Y, Tamaoki N, Shibuya M . A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors. Jpn J Cancer Res. 1990; 81(8):773-9. PMC: 5918101. DOI: 10.1111/j.1349-7006.1990.tb02644.x. View

16.

Smith J, Tachibana I, Lee H, Qian J, Pohl U, Mohrenweiser H . Mapping of the chromosome 19 q-arm glioma tumor suppressor gene using fluorescence in situ hybridization and novel microsatellite markers. Genes Chromosomes Cancer. 2000; 29(1):16-25. DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1007>3.3.co;2-9. View

17.

Listernick R, Charrow J, Greenwald M, Esterly N . Optic gliomas in children with neurofibromatosis type 1. J Pediatr. 1989; 114(5):788-92. DOI: 10.1016/s0022-3476(89)80137-4. View

18.

Jenkins R, Kimmel D, Moertel C, Schultz C, Scheithauer B, Kelly P . A cytogenetic study of 53 human gliomas. Cancer Genet Cytogenet. 1989; 39(2):253-79. DOI: 10.1016/0165-4608(89)90192-1. View

19.

Chan T, Yuen S, Chung L, Ho J, Kwan K, Fan Y . Germline hMSH2 and differential somatic mutations in patients with Turcot's syndrome. Genes Chromosomes Cancer. 1999; 25(2):75-81. View

20.

Bates S, Phillips A, Clark P, Stott F, Peters G, Ludwig R . p14ARF links the tumour suppressors RB and p53. Nature. 1998; 395(6698):124-5. DOI: 10.1038/25867. View