Paul Kleihues
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Explore the profile of Paul Kleihues including associated specialties, affiliations and a list of published articles.
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50
Citations
18043
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Recent Articles
1.
Hegi M, Kleihues P, Wen P, Suva M
Neuro Oncol
. 2018 Mar;
20(5):579-581.
PMID: 29584921
No abstract available.
2.
Forsstrom L, Sumi K, Makinen M, Oh J, Herva R, Kleihues P, et al.
J Neuropathol Exp Neurol
. 2017 Sep;
76(10):848-853.
PMID: 28922847
We previously reported a patient who had developed 2 glioblastomas at the age of 54 and 64 years, respectively. The first glioblastoma in the right frontal lobe was treated with...
3.
Wang Q, Satomi K, Oh J, Hutter B, Brors B, Diessl N, et al.
Am J Pathol
. 2016 Sep;
186(10):2569-76.
PMID: 27658714
A single dose of N-ethyl-N-nitrosourea (ENU) during late prenatal or early postnatal development induces a high incidence of malignant schwannomas and gliomas in rats. Although T->A mutations in the transmembrane...
4.
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
Louis D, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee W, et al.
Acta Neuropathol
. 2016 May;
131(6):803-20.
PMID: 27157931
The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO...
5.
Oh J, Ohta T, Nonoguchi N, Satomi K, Capper D, Pierscianek D, et al.
Brain Pathol
. 2015 Oct;
26(4):517-22.
PMID: 26443480
The majority of glioblastomas develop rapidly with a short clinical history (primary glioblastoma IDH wild-type), whereas secondary glioblastomas progress from diffuse astrocytoma or anaplastic astrocytoma. IDH mutations are the genetic...
6.
Ohta T, Kim Y, Oh J, Satomi K, Nonoguchi N, Keyvani K, et al.
J Neuropathol Exp Neurol
. 2014 Sep;
73(10):908-15.
PMID: 25192052
Gemistocytic astrocytoma (World Health Organization grade II) is a rare variant of diffuse astrocytoma that is characterized by the presence of neoplastic gemistocytes and has a significantly less favorable prognosis....
7.
Kim Y, Ohta T, Oh J, Le Calvez-Kelm F, McKay J, Voegele C, et al.
Am J Pathol
. 2014 Jul;
184(9):2374-81.
PMID: 25041856
Exome DNA sequencing of blood samples from a Li-Fraumeni family with a TP53 germline mutation (codon 236 deletion) and multiple nervous system tumors revealed additional germline mutations. Missense mutations in...
8.
Louis D, Perry A, Burger P, Ellison D, Reifenberger G, von Deimling A, et al.
Brain Pathol
. 2014 Jul;
24(5):429-35.
PMID: 24990071
Major discoveries in the biology of nervous system tumors have raised the question of how non-histological data such as molecular information can be incorporated into the next World Health Organization...
9.
Ohgaki H, Burger P, Kleihues P
Clin Cancer Res
. 2014 Feb;
20(7):2013.
PMID: 24557936
No abstract available.
10.
Nonoguchi N, Ohta T, Oh J, Kim Y, Kleihues P, Ohgaki H
Acta Neuropathol
. 2013 Aug;
126(6):931-7.
PMID: 23955565
Telomerase reverse transcriptase (TERT) is up-regulated in a variety of human neoplasms. Mutations in the core promoter region of the TERT gene, which increases promoter activity, have been reported in...