Effects of Cetylpyridinium Chloride Resistance and Treatment on Fluconazole Activity Versus Candida Albicans

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2005 Jan 28

PMID 15673785

Citations 3

Authors

Merritt P Edlind

W Lamar Smith

Thomas D Edlind

Affiliations

Soon will be listed here.

Abstract

Mouthwash antiseptic cetylpyridinium chloride (CPC) has potent activity against Candida albicans; however, two of five azole-resistant strains showed reduced CPC susceptibility. To further examine the potential for cross-resistance, CPC-resistant mutants were selected in vitro and their fluconazole susceptibility was tested. MICs were unchanged, and trailing growth generally decreased. With CPC-fluconazole combinations, both antagonism and synergism were observed, which can be explained, in part, by CDR1-CDR2 multidrug transporter upregulation.

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References

Fraise A . Biocide abuse and antimicrobial resistance--a cause for concern?. J Antimicrob Chemother. 2001; 49(1):11-2. DOI: 10.1093/jac/49.1.11. View

Perea S, Lopez-Ribot J, Kirkpatrick W, McAtee R, Santillan R, Martinez M . Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 2001; 45(10):2676-84. PMC: 90716. DOI: 10.1128/AAC.45.10.2676-2684.2001. View

Russell A . Mechanisms of antimicrobial action of antiseptics and disinfectants: an increasingly important area of investigation. J Antimicrob Chemother. 2002; 49(4):597-9. DOI: 10.1093/jac/49.4.597. View

White T, Holleman S, Dy F, Mirels L, Stevens D . Resistance mechanisms in clinical isolates of Candida albicans. Antimicrob Agents Chemother. 2002; 46(6):1704-13. PMC: 127245. DOI: 10.1128/AAC.46.6.1704-1713.2002. View

Smith W, Edlind T . Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. Antimicrob Agents Chemother. 2002; 46(11):3532-9. PMC: 128736. DOI: 10.1128/AAC.46.11.3532-3539.2002. View

Gilbert P, McBain A . Potential impact of increased use of biocides in consumer products on prevalence of antibiotic resistance. Clin Microbiol Rev. 2003; 16(2):189-208. PMC: 153147. DOI: 10.1128/CMR.16.2.189-208.2003. View

Phillips B, Kaplan W . Effect of cetylpyridinium chloride on pathogenic fungi and Nocardia asteroides in sputum. J Clin Microbiol. 1976; 3(3):272-6. PMC: 274282. DOI: 10.1128/jcm.3.3.272-276.1976. View

Hiom S, Furr J, Russell A, Dickinson J . Effects of chlorhexidine diacetate and cetylpyridinium chloride on whole cells and protoplasts of Saccharomyces cerevisiae. Microbios. 1993; 74(299):111-20. View

Nakamoto K, Tamamoto M, Hamada T . In vitro effectiveness of mouthrinses against Candida albicans. Int J Prosthodont. 1995; 8(5):486-9. View

10.

Sanglard D, Ischer F, Monod M, Bille J . Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology (Reading). 1997; 143 ( Pt 2):405-416. DOI: 10.1099/00221287-143-2-405. View

11.

Giuliana G, Pizzo G, Milici M, Musotto G, Giangreco R . In vitro antifungal properties of mouthrinses containing antimicrobial agents. J Periodontol. 1997; 68(8):729-33. DOI: 10.1902/jop.1997.68.8.729. View

12.

Rex J, Nelson P, Paetznick V, Espinel-Ingroff A, Anaissie E . Optimizing the correlation between results of testing in vitro and therapeutic outcome in vivo for fluconazole by testing critical isolates in a murine model of invasive candidiasis. Antimicrob Agents Chemother. 1998; 42(1):129-34. PMC: 105467. DOI: 10.1128/AAC.42.1.129. View

13.

Meier S, Collier C, Scaletta M, Stephens J, KIMBROUGH R, Kettering J . An in vitro investigation of the efficacy of CPC for use in toothbrush decontamination. J Dent Hyg. 1996; 70(4):161-5. View

14.

McDonnell G, Russell A . Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999; 12(1):147-79. PMC: 88911. DOI: 10.1128/CMR.12.1.147. View

15.

Giuliana G, Pizzo G, Milici M, Giangreco R . In vitro activities of antimicrobial agents against Candida species. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 87(1):44-9. DOI: 10.1016/s1079-2104(99)70293-3. View

16.

Henry K, Cruz M, Katiyar S, Edlind T . Antagonism of azole activity against Candida albicans following induction of multidrug resistance genes by selected antimicrobial agents. Antimicrob Agents Chemother. 1999; 43(8):1968-74. PMC: 89399. DOI: 10.1128/AAC.43.8.1968. View

17.

Akimitsu N, Hamamoto H, Inoue R, Shoji M, Akamine A, Takemori K . Increase in resistance of methicillin-resistant Staphylococcus aureus to beta-lactams caused by mutations conferring resistance to benzalkonium chloride, a disinfectant widely used in hospitals. Antimicrob Agents Chemother. 2000; 43(12):3042-3. PMC: 89614. DOI: 10.1128/AAC.43.12.3042. View

18.

Chuanchuen R, Beinlich K, Hoang T, Becher A, Karkhoff-Schweizer R, Schweizer H . Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ. Antimicrob Agents Chemother. 2001; 45(2):428-32. PMC: 90308. DOI: 10.1128/AAC.45.2.428-432.2001. View

19.

Sanglard D, Odds F . Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences. Lancet Infect Dis. 2002; 2(2):73-85. DOI: 10.1016/s1473-3099(02)00181-0. View