Object Naming and Semantic Fluency Among Individuals with Genetic Risk for Alzheimer's Disease

Overview

Journal Int J Geriatr Psychiatry

Specialties Geriatrics
Psychiatry

Date 2005 Jan 22

PMID 15660408

Citations 10

Authors

Karen J Miller

Steven A Rogers

Prabha Siddarth

Gary W Small

Affiliations

Soon will be listed here.

Abstract

Objectives: This study longitudinally examined the object naming and semantic fluency of individuals who are at risk for developing Alzheimer's disease (AD) by virtue of having APOE-4 or a family history of AD.

Methods: A total of 108 participants (40 with a family history of AD and 43 with APOE-4) completed the Boston Naming Test and the Animal Naming task at initial assessment and after two years.

Results: At baseline, object naming was significantly lower for those with both risk factors, F(2, 99) = 5.72, p < 0.01, but those with either risk factor had significantly lower scores at follow-up, F(2, 99) = 3.41, p < 0.05. Semantic fluency (animal naming) was reduced among subjects with the APOE-4 allele at baseline, F(1, 100) = 4.02, p < 0.05, but it was not associated with either risk factor at follow-up.

Conclusions: These deficits may be associated with a prodromal risk for AD and may serve as pre-symptomatic markers for the development of AD.

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