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Language Performance in Postmenopausal Women with and Without Hormone Therapy and Men

Overview
Journal Aging health
Publisher Future Medicine
Specialty Geriatrics
Date 2015 Feb 24
PMID 25705244
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Abstract

Aims: In the current study, we explored the potential effects of hormone therapy (HT) on language functioning in healthy, postmenopausal women and compared them with men of similar ages.

Materials & Methods: Language functioning on tasks of verbal fluency and object naming was examined in 100 participants (mean age: 61.9 years; 33 HT users, 15 HT non-users and 52 men) at baseline and follow-up (mean follow-up time period: 2.6 years).

Results: At baseline, men had higher composite language scores than HT users. However, HT users demonstrated more improvement over time compared with men, whereas HT non-users performed similarly to men, with no improvement over time. Longer duration of HT use was not associated with improved performance on language tests.

Conclusion: These results suggest an association between HT use and better language ability in postmenopausal women.

References
1.
Chen S, Nilsen J, Brinton R . Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications. Endocrinology. 2006; 147(11):5303-13. DOI: 10.1210/en.2006-0495. View

2.
Buschke H, Fuld P . Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology. 1974; 24(11):1019-25. DOI: 10.1212/wnl.24.11.1019. View

3.
Sherwin B . The critical period hypothesis: can it explain discrepancies in the oestrogen-cognition literature?. J Neuroendocrinol. 2007; 19(2):77-81. DOI: 10.1111/j.1365-2826.2006.01508.x. View

4.
Miller K, Conney J, Rasgon N, Fairbanks L, Small G . Mood symptoms and cognitive performance in women estrogen users and nonusers and men. J Am Geriatr Soc. 2002; 50(11):1826-30. DOI: 10.1046/j.1532-5415.2002.50511.x. View

5.
Toran-Allerand C, Miranda R, Bentham W, Sohrabji F, Brown T, Hochberg R . Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proc Natl Acad Sci U S A. 1992; 89(10):4668-72. PMC: 49144. DOI: 10.1073/pnas.89.10.4668. View