Children of Persons with Alzheimer Disease: What Does the Future Hold?

Overview

Journal Alzheimer Dis Assoc Disord

Specialties Neurology
Psychiatry

Date 2008 Mar 5

PMID 18317242

Citations 18

Authors

Lissy Jarvik

Asenath LaRue

Deborah Blacker

Margaret Gatz

Claudia Kawas

John J McArdle

John C Morris

James A Mortimer

John M Ringman

Linda Ercoli

Nelson Freimer

Izabella Gokhman

Jennifer J Manly

Brenda L Plassman

Natalie Rasgon

Jeffrey Scott Roberts

Trey Sunderland

Gary E Swan

Phillip A Wolf

Alan B Zonderman

Affiliations

Soon will be listed here.

Abstract

Children of persons with Alzheimer disease (AD), as a group, face an increased risk of developing AD. Many of them, throughout their adult lives, seek input on how to reduce their chances of one day suffering their parent's fate. We examine the state of knowledge with respect to risk and protective factors for AD and recommend a research agenda with special emphasis on AD offspring.

Citing Articles

Community memory screening as a strategy for recruiting older adults into Alzheimer's disease research.

Peavy G, Jenkins C, Little E, Gigliotti C, Calcetas A, Edland S Alzheimers Res Ther. 2020; 12(1):78.

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Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study.

Gaitan J, Boots E, Dougherty R, Ma Y, Edwards D, Mitchell C J Alzheimers Dis Rep. 2020; 4(1):107-121.

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Early-Onset Alzheimer Disease.

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Family History of Alzheimer's Disease is Associated with Impaired Perceptual Discrimination of Novel Objects.

Mason E, Hussey E, Molitor R, Ko P, Donahue M, Ally B J Alzheimers Dis. 2017; 57(3):735-745.

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Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer's Study.

Atem F, Qian J, Maye J, Johnson K, Betensky R J R Stat Soc Ser C Appl Stat. 2017; 66(2):313-328.

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References

Fratiglioni L, De Ronchi D, Aguero-Torres H . Worldwide prevalence and incidence of dementia. Drugs Aging. 1999; 15(5):365-75. DOI: 10.2165/00002512-199915050-00004. View

Ott A, Stolk R, Van Harskamp F, Pols H, Hofman A, Breteler M . Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology. 1999; 53(9):1937-42. DOI: 10.1212/wnl.53.9.1937. View

Fratiglioni L, Launer L, Andersen K, Breteler M, Copeland J, Dartigues J . Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000; 54(11 Suppl 5):S10-5. View

Backman L, Jones S, Berger A, Jonsson Laukka E, Small B . Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis. Neuropsychology. 2005; 19(4):520-31. DOI: 10.1037/0894-4105.19.4.520. View

Kamboh M . Molecular genetics of late-onset Alzheimer's disease. Ann Hum Genet. 2004; 68(Pt 4):381-404. DOI: 10.1046/j.1529-8817.2004.00110.x. View

Johnson S, Schmitz T, Trivedi M, Ries M, Torgerson B, Carlsson C . The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation. J Neurosci. 2006; 26(22):6069-76. PMC: 2684824. DOI: 10.1523/JNEUROSCI.0959-06.2006. View

Baskin F, Rosenberg R, Iyer L, Hynan L, Cullum C . Platelet APP isoform ratios correlate with declining cognition in AD. Neurology. 2000; 54(10):1907-9. DOI: 10.1212/wnl.54.10.1907. View

Moffat S, Szekely C, Zonderman A, Kabani N, Resnick S . Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype. Neurology. 2000; 55(1):134-6. DOI: 10.1212/wnl.55.1.134. View

Silverman J, Smith C, Marin D, Mohs R, Propper C . Familial patterns of risk in very late-onset Alzheimer disease. Arch Gen Psychiatry. 2003; 60(2):190-7. DOI: 10.1001/archpsyc.60.2.190. View

10.

Zuo L, van Dyck C, Luo X, Kranzler H, Yang B, Gelernter J . Variation at APOE and STH loci and Alzheimer's disease. Behav Brain Funct. 2006; 2:13. PMC: 1526745. DOI: 10.1186/1744-9081-2-13. View

11.

Simonsen A, McGuire J, Hansson O, Zetterberg H, Podust V, Davies H . Novel panel of cerebrospinal fluid biomarkers for the prediction of progression to Alzheimer dementia in patients with mild cognitive impairment. Arch Neurol. 2007; 64(3):366-70. DOI: 10.1001/archneur.64.3.366. View

12.

Petersen R, Morris J . Mild cognitive impairment as a clinical entity and treatment target. Arch Neurol. 2005; 62(7):1160-3. DOI: 10.1001/archneur.62.7.1160. View

13.

Cummings J . Alzheimer's disease. N Engl J Med. 2004; 351(1):56-67. DOI: 10.1056/NEJMra040223. View

14.

Masters C, Beyreuther K . Alzheimer's disease. BMJ. 1998; 316(7129):446-8. PMC: 2665603. DOI: 10.1136/bmj.316.7129.446. View

15.

Kawas C, Corrada M, Brookmeyer R, Morrison A, Resnick S, Zonderman A . Visual memory predicts Alzheimer's disease more than a decade before diagnosis. Neurology. 2003; 60(7):1089-93. DOI: 10.1212/01.wnl.0000055813.36504.bf. View

16.

Cupples L, Farrer L, Sadovnick A, Relkin N, Whitehouse P, Green R . Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study. Genet Med. 2004; 6(4):192-6. DOI: 10.1097/01.gim.0000132679.92238.58. View

17.

Goate A, Chartier-Harlin M, Mullan M, Brown J, Crawford F, Fidani L . Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 1991; 349(6311):704-6. DOI: 10.1038/349704a0. View

18.

Mayeux R . Gene-environment interaction in late-onset Alzheimer disease: the role of apolipoprotein-epsilon4. Alzheimer Dis Assoc Disord. 1999; 12 Suppl 3:S10-5. View

19.

Andel R, Crowe M, Pedersen N, Mortimer J, Crimmins E, Johansson B . Complexity of work and risk of Alzheimer's disease: a population-based study of Swedish twins. J Gerontol B Psychol Sci Soc Sci. 2005; 60(5):P251-8. DOI: 10.1093/geronb/60.5.p251. View

20.

Yaffe K, Barrett-Connor E, Lin F, Grady D . Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol. 2002; 59(3):378-84. DOI: 10.1001/archneur.59.3.378. View