TACI and BAFF-R Mediate Isotype Switching in B Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2005 Jan 5

PMID 15630136

Citations 230

Authors

Emanuela Castigli

Stephen A Wilson

Sumi Scott

Fatma Dedeoglu

Shengli Xu

Kong-Peng Lam

Richard J Bram

Haifa Jabara

Raif S Geha

Affiliations

Soon will be listed here.

Abstract

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.

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References

Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T . Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 2000; 102(5):553-63. DOI: 10.1016/s0092-8674(00)00078-7. View

Zelazowski P, Carrasco D, Rosas F, Moorman M, Bravo R, Snapper C . B cells genetically deficient in the c-Rel transactivation domain have selective defects in germline CH transcription and Ig class switching. J Immunol. 1997; 159(7):3133-9. View

Xu S, Lam K . B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol Cell Biol. 2001; 21(12):4067-74. PMC: 87068. DOI: 10.1128/MCB.21.12.4067-4074.2001. View

von Bulow G, Van Deursen J, Bram R . Regulation of the T-independent humoral response by TACI. Immunity. 2001; 14(5):573-82. DOI: 10.1016/s1074-7613(01)00130-3. View

Yan M, Wang H, Chan B, Roose-Girma M, Erickson S, Baker T . Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol. 2001; 2(7):638-43. DOI: 10.1038/89790. View

Thompson J, Bixler S, Qian F, Vora K, Scott M, Cachero T . BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science. 2001; 293(5537):2108-11. DOI: 10.1126/science.1061965. View

Ahonen C, Manning E, Erickson L, OConnor B, Lind E, Pullen S . The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. Nat Immunol. 2002; 3(5):451-6. PMC: 2834483. DOI: 10.1038/ni792. View

Litinskiy M, Nardelli B, Hilbert D, He B, Schaffer A, Casali P . DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol. 2002; 3(9):822-9. PMC: 4621779. DOI: 10.1038/ni829. View

Seshasayee D, Valdez P, Yan M, Dixit V, Tumas D, Grewal I . Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity. 2003; 18(2):279-88. DOI: 10.1016/s1074-7613(03)00025-6. View

10.

Mackay F, Schneider P, Rennert P, Browning J . BAFF AND APRIL: a tutorial on B cell survival. Annu Rev Immunol. 2002; 21:231-64. DOI: 10.1146/annurev.immunol.21.120601.141152. View

11.

Gulino A, Notarangelo L . Hyper IgM syndromes. Curr Opin Rheumatol. 2003; 15(4):422-9. DOI: 10.1097/00002281-200307000-00009. View

12.

Geha R, Jabara H, Brodeur S . The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol. 2003; 3(9):721-32. DOI: 10.1038/nri1181. View

13.

Xie P, Hostager B, Bishop G . Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes. J Exp Med. 2004; 199(5):661-71. PMC: 2213302. DOI: 10.1084/jem.20031255. View

14.

Castigli E, Scott S, Dedeoglu F, Bryce P, Jabara H, Bhan A . Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A. 2004; 101(11):3903-8. PMC: 374342. DOI: 10.1073/pnas.0307348101. View

15.

Duff G, Atkins E . The inhibitory effect of polymyxin B on endotoxin-induced endogenous pyrogen production. J Immunol Methods. 1982; 52(3):333-40. DOI: 10.1016/0022-1759(82)90005-9. View

16.

Jabara H, Laouini D, Tsitsikov E, Mizoguchi E, Bhan A, Castigli E . The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity. 2002; 17(3):265-76. DOI: 10.1016/s1074-7613(02)00394-1. View

17.

Castigli E, Alt F, Davidson L, Bottaro A, Mizoguchi E, Bhan A . CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc Natl Acad Sci U S A. 1994; 91(25):12135-9. PMC: 45391. DOI: 10.1073/pnas.91.25.12135. View

18.

Castigli E, Fuleihan R, Ramesh N, Tsitsikov E, Tsytsykova A, Geha R . CD40 ligand/CD40 deficiency. Int Arch Allergy Immunol. 1995; 107(1-3):37-9. DOI: 10.1159/000236923. View

19.

Hollander G, Castigli E, Kulbacki R, Su M, Burakoff S, Gutierrez-Ramos J . Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice. Proc Natl Acad Sci U S A. 1996; 93(10):4994-8. PMC: 39394. DOI: 10.1073/pnas.93.10.4994. View

20.

Hodgkin P, Lee J, Lyons A . B cell differentiation and isotype switching is related to division cycle number. J Exp Med. 1996; 184(1):277-81. PMC: 2192686. DOI: 10.1084/jem.184.1.277. View