Characterization of Rapidly Progressive Osteoarthritis of the Hip in Its Early Stage

Overview

Journal Eur J Rheumatol

Publisher Aves

Specialty Rheumatology

Date 2020 May 9

PMID 32384049

Citations 12

Authors

Tadashi Yasuda

Kazuhiro Matsunaga

Takumi Hashimura

Yoshihiro Tsukamoto

Tatsuya Sueyoshi

Satoshi Ota

Satoshi Fujita

Eijiro Onishi

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to characterize the process of disease progression in the early stage of rapidly progressive osteoarthritis of the hip (RPOH) and clarify its association with potential pathological factors of RPOH.

Methods: This monocentric retrospective study included 41 female patients who met the criteria for RPOH, chondrolysis >2 mm during 12 months from the onset of hip pain based on a series of radiographs and computed tomography. This study also included 9 female patients with osteoarthritis secondary to developmental dysplasia of the hip (DDH) who demonstrated chondrolysis >2 mm during 12 months from the onset of hip pain. Cortical thickness index (CTI) correlated with bone mineral density of the hip, pelvic tilt, and serum concentrations of matrix metalloproteinase (MMP)-3 were analyzed.

Results: RPOH was classified into two types based on the absence (type 1, n=17) and presence (type 2, n=24) of subsequent femoral head destruction within 12 months after the onset of hip pain. MMP-3 significantly increased in RPOH type 2 compared with type 1 and DDH. Increased posterior pelvic tilt was found in RPOH type 2 compared with DDH. Logistic regression and receiver operating characteristic curve analyses indicated that MMP-3 may be associated with differentiation between RPOH types 1 and 2. No difference was found in the CTI between the RPOH types and DDH.

Conclusion: Disease progression of RPOH during 12 months after the onset of hip pain could be classified into two distinct types based on the absence (type 1) and presence (type 2) of femoral head destruction in association with MMP-3 and pelvic tilt as biological and mechanical factors, respectively. MMP-3 may be helpful to differentiate these two types in the early stage of RPOH.

Citing Articles

The Presentation, Clinical Diagnosis, Risk Factors, and Management of Rapidly Progressive Hip Osteoarthritis: A Narrative Literature Review.

Oprisan A, Feier A, Zuh S, Russu O, Pop T J Clin Med. 2024; 13(20).

PMID: 39458144 PMC: 11509174. DOI: 10.3390/jcm13206194.

Rapidly destructive hip osteoarthritis: a diagnosis not to miss.

Chau H, Wong P, Pan N, Ma K Br J Radiol. 2024; 97(1161):1526-1533.

PMID: 38936340 PMC: 11332667. DOI: 10.1093/bjr/tqae126.

Rapid Osteoarthritis and Femoral Head Collapse: A Case Series.

Rana P, Johnson A, Turcotte J, King P J Orthop Case Rep. 2024; 14(5):141-146.

PMID: 38784863 PMC: 11111228. DOI: 10.13107/jocr.2024.v14.i05.4464.

Rapidly Progressive Osteoarthritis of the Hip: A Prospective Study.

Montero Furelos L, De Castro Carrasco A, Cons Lamas S, Sanchez Sierra F, Caeiro-Rey J J Clin Med. 2024; 13(9).

PMID: 38730996 PMC: 11084505. DOI: 10.3390/jcm13092467.

Investigating sagittal spinopelvic alignment and equivalent stress on the femoral head in patients with rapidly destructive coxarthrosis.

Orita K, Okuzu Y, Shimizu T, Goto K, Kuroda Y, Kawai T Eur J Orthop Surg Traumatol. 2023; 34(2):901-908.

PMID: 37770595 DOI: 10.1007/s00590-023-03733-5.

References

Garnero P, Conrozier T, Christgau S, Mathieu P, Delmas P, Vignon E . Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis. Ann Rheum Dis. 2003; 62(10):939-43. PMC: 1754328. DOI: 10.1136/ard.62.10.939. View

Nishihara S, Sugano N, Nishii T, Ohzono K, Yoshikawa H . Measurements of pelvic flexion angle using three-dimensional computed tomography. Clin Orthop Relat Res. 2003; (411):140-51. DOI: 10.1097/01.blo.0000069891.31220.fd. View

Bock G, Garcia A, Weisman M, Major P, Lyttle D, Haghighi P . Rapidly destructive hip disease: clinical and imaging abnormalities. Radiology. 1993; 186(2):461-6. DOI: 10.1148/radiology.186.2.8421751. View

Zazgyva A, Gurzu S, Gergely I, Jung I, Roman C, Pop T . Clinico-radiological diagnosis and grading of rapidly progressive osteoarthritis of the hip. Medicine (Baltimore). 2017; 96(12):e6395. PMC: 5371469. DOI: 10.1097/MD.0000000000006395. View

Yamamoto T, Bullough P . The role of subchondral insufficiency fracture in rapid destruction of the hip joint: a preliminary report. Arthritis Rheum. 2000; 43(11):2423-7. DOI: 10.1002/1529-0131(200011)43:11<2423::AID-ANR8>3.0.CO;2-Z. View

Yoshimoto H, Sato S, Masuda T, Kanno T, Shundo M, Hyakumachi T . Spinopelvic alignment in patients with osteoarthrosis of the hip: a radiographic comparison to patients with low back pain. Spine (Phila Pa 1976). 2005; 30(14):1650-7. DOI: 10.1097/01.brs.0000169446.69758.fa. View

Sugano N, Ohzono K, Nishii T, Sakai T, Haraguchi K, Yoshikawa H . Early MRI findings of rapidly destructive coxopathy. Magn Reson Imaging. 2001; 19(1):47-50. DOI: 10.1016/s0730-725x(01)00221-1. View

Watanabe W, Sato K, Itoi E, Yang K, Watanabe H . Posterior pelvic tilt in patients with decreased lumbar lordosis decreases acetabular femoral head covering. Orthopedics. 2002; 25(3):321-4. DOI: 10.3928/0147-7447-20020301-16. View

Kim N, Kadono Y, Takami M, Lee J, Lee S, Okada F . Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med. 2005; 202(5):589-95. PMC: 2212875. DOI: 10.1084/jem.20050978. View

10.

Lequesne M . [Rapid destructive coxarthritis]. Rhumatologie. 1970; 22(2):51-63. View

11.

Abe H, Sakai T, Ogawa T, Takao M, Nishii T, Nakamura N . Characteristics of bone turnover markers in rapidly destructive coxopathy. J Bone Miner Metab. 2016; 35(4):412-418. DOI: 10.1007/s00774-016-0769-4. View

12.

Yeung Y, Chiu K, Yau W, Tang W, Cheung W, Ng T . Assessment of the proximal femoral morphology using plain radiograph-can it predict the bone quality?. J Arthroplasty. 2006; 21(4):508-13. DOI: 10.1016/j.arth.2005.04.037. View

13.

Ogawa K, Mawatari M, Komine M, Shigematsu M, Kitajima M, Kukita A . Mature and activated osteoclasts exist in the synovium of rapidly destructive coxarthrosis. J Bone Miner Metab. 2007; 25(6):354-60. DOI: 10.1007/s00774-007-0761-0. View

14.

Morimoto T, Kitajima M, Tsukamoto M, Yoshihara T, Sonohata M, Mawatari M . Sagittal spino-pelvic alignment in rapidly destructive coxarthrosis. Eur Spine J. 2017; 27(2):475-481. DOI: 10.1007/s00586-017-5282-5. View

15.

Nguyen B, Hoshino H, Togawa D, Matsuyama Y . Cortical Thickness Index of the Proximal Femur: A Radiographic Parameter for Preliminary Assessment of Bone Mineral Density and Osteoporosis Status in the Age 50 Years and Over Population. Clin Orthop Surg. 2018; 10(2):149-156. PMC: 5964262. DOI: 10.4055/cios.2018.10.2.149. View

16.

Offierski C, Macnab I . Hip-spine syndrome. Spine (Phila Pa 1976). 1983; 8(3):316-21. DOI: 10.1097/00007632-198304000-00014. View

17.

Baumgartner R, Heeren N, Quast D, Babst R, Brunner A . Is the cortical thickness index a valid parameter to assess bone mineral density in geriatric patients with hip fractures?. Arch Orthop Trauma Surg. 2015; 135(6):805-10. DOI: 10.1007/s00402-015-2202-1. View

18.

Yokota K, Sato K, Miyazaki T, Kitaura H, Kayama H, Miyoshi F . Combination of tumor necrosis factor α and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo. Arthritis Rheumatol. 2014; 66(1):121-9. DOI: 10.1002/art.38218. View

19.

Watanabe W, Itoi E, Yamada S . Early MRI findings of rapidly destructive coxarthrosis. Skeletal Radiol. 2002; 31(1):35-8. DOI: 10.1007/s00256-001-0445-0. View

20.

Berger C, Kroner A, Stiegler H, Leitha T, Engel A . Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip. Int Orthop. 2004; 29(1):1-5. PMC: 3456947. DOI: 10.1007/s00264-004-0608-4. View