Going Both Ways: Immune Regulation Via CD1d-dependent NKT Cells

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2004 Nov 17

PMID 15545985

Citations 333

Authors

Dale I Godfrey

Mitchell Kronenberg

Affiliations

Soon will be listed here.

Abstract

NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation of immune responses associated with a broad range of diseases, including autoimmunity, infectious diseases, and cancer. In stark contrast to both conventional T lymphocytes and other types of Tregs, NKT cells are reactive to the nonclassical class I antigen-presenting molecule CD1d, and they recognize glycolipid antigens rather than peptides. Moreover, they can either up- or downregulate immune responses by promoting the secretion of Th1, Th2, or immune regulatory cytokines. This review will explore the diverse influences of these cells in various disease models, their ability to suppress or enhance immunity, and the potential for manipulating these cells as a novel form of immunotherapy.

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