Polyunsaturated Fatty Acid Regulation of Gene Expression

Overview

Journal Nutr Rev

Publisher Oxford University Press

Specialty Nutritional Sciences

Date 2004 Oct 23

PMID 15497766

Citations 57

Authors

Harini Sampath

James M Ntambi

Affiliations

Soon will be listed here.

Abstract

Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-alpha, HNF-4alpha, and LXRalpha in mediating the nuclear effects of PUFAs are addressed.

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