Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5

Overview

Journal Science

Specialty Science

Date 2004 Oct 16

PMID 15486300

Citations 134

Authors

Michael M Lederman

Ronald S Veazey

Robin Offord

Donald E Mosier

Jason Dufour

Megan Mefford

Michael Piatak Jr

Jeffrey D Lifson

Janelle R Salkowitz

Benigno Rodriguez

Andrew Blauvelt

Oliver Hartley

Affiliations

Soon will be listed here.

Abstract

Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention.

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