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Cysteine Proteinases of Parasitic Protozoa

Overview
Journal Parasitol Today
Specialty Parasitology
Date 1990 Aug 1
PMID 15463360
Citations 28
Authors
M J North
J C Mottram
G H Coombs
Affiliations
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Abstract

Proteinases are involved with many processes in living organisms. In recent years, there has been increasing interest in elucidating the functions the enzymes perform in parasites. These studies have revealed that one class of proteinases, the cysteine proteinases, predominates in many parasitic protozoa. In this article Mick North, Jeremy Mottram and Graham Coombs review what is known about the cysteine proteinases of parasitic protozoa and discuss the approaches being pursued in attempts to design antiparasite drugs based on inhibitors or substrates of these enzymes.

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