G H Coombs
Overview
Explore the profile of G H Coombs including associated specialties, affiliations and a list of published articles.
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Articles
148
Citations
1883
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Recent Articles
1.
Shaw C, Imamura H, Downing T, Blackburn G, Westrop G, Cotton J, et al.
Antimicrob Agents Chemother
. 2019 Oct;
64(1).
PMID: 31658971
Understanding the mechanism(s) underpinning drug resistance could lead to novel treatments to reverse the increased tolerance of a pathogen. In this study, paromomycin (PMM) resistance (PMM) was induced in three...
2.
Shaw C, Lonchamp J, Downing T, Imamura H, Freeman T, Cotton J, et al.
Mol Microbiol
. 2015 Dec;
99(6):1134-48.
PMID: 26713880
In this study, we followed the genomic, lipidomic and metabolomic changes associated with the selection of miltefosine (MIL) resistance in two clinically derived Leishmania donovani strains with different inherent resistance...
3.
Castanys-Munoz E, Brown E, Coombs G, Mottram J
Cell Death Dis
. 2012 Sep;
3:e385.
PMID: 22951982
Metacaspases (MCAs) are caspase family cysteine peptidases that have been implicated in cell death processes in plants, fungi and protozoa. MCAs have also been suggested to be involved in cell...
4.
Alsaadi M, Italia J, Mullen A, Kumar M, Candlish A, Williams R, et al.
J Control Release
. 2012 Apr;
160(3):685-91.
PMID: 22516093
Amphotericin B (AMB) is used to treat both fungal and leishmanial infections, which are of major significance to human health. Clinical use of free AMB is limited by its nephrotoxicity,...
5.
Silva A, Tavares J, Silvestre R, Ouaissi A, Coombs G, Cordeiro-da-Silva A
Parasite Immunol
. 2012 Mar;
34(6):345-50.
PMID: 22416787
The need to develop an effective vaccine against leishmaniasis to prevent the 2 million new cases each year led to the search for antigens able to elicit protection against infection...
6.
Gornik S, Westrop G, Coombs G, Neil D
Mol Biol Rep
. 2009 Jul;
37(4):2009-19.
PMID: 19642014
Calpains are ubiquitous cysteine-proteases found in many, if not all, living organisms and their roles within these organisms are diverse, ranging from the mediation of cytoskeletal remodeling to the regulation...
7.
McMillan P, Patzewitz E, Young S, Westrop G, Coombs G, Engman L, et al.
Parasitology
. 2008 Nov;
136(1):27-33.
PMID: 18980703
Thioredoxin reductase (TrxR), a NADPH-dependent disulfide oxidoreductase, is vital in numerous cellular processes including defence against reactive oxygen species, cell proliferation and signal transduction. TrxRs occur in 2 forms, a...
8.
Ambit A, Fasel N, Coombs G, Mottram J
Cell Death Differ
. 2007 Sep;
15(1):113-22.
PMID: 17901875
Metacaspases (MCAs) are distant orthologues of caspases and have been proposed to play a role in programmed cell death in yeast and plants, but little is known about their function...
9.
Small H, Shields J, Neil D, Taylor A, Coombs G
J Invertebr Pathol
. 2006 Dec;
94(3):175-83.
PMID: 17156792
Parasitic dinoflagellates of the genus Hematodinium infect several commercially important decapod crustaceans. Different species of Hematodinium have different levels of virulence in their respective hosts. Enzyme activities were studied from...
10.