Repeated Restraint Stress Alters Hippocampal Glutamate Uptake and Release in the Rat

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2004 Sep 30

PMID 15453265

Citations 22

Authors

Fernanda Urruth Fontella

Deusa Aparecida Vendite

Angela Sampaio Tabajara

Lisiane O Porciuncula

Iraci Lucena Da Silva Torres

Fluvia Melina Jardim

Lucia Martini

Diogo O Souza

Carlos Alexandre Netto

Carla Dalmaz

Affiliations

Soon will be listed here.

Abstract

Glutamatergic mechanisms are thought to be involved in stress-induced changes of brain function, especially in the hippocampus. We hypothesized that alterations caused by the hormonal changes associated with chronic and acute stress may affect glutamate uptake and release from hippocampal synaptosomes in Wistar rats. It was found that [3H]glutamate uptake and release by hippocampal nerve endings, when measured 24 h after 1 h of acute restraint, presented no significant difference. The exposure to repeated restraint stress for 40 days increased neuronal presynaptic [3H]glutamate uptake as well as basal and K+-stimulated glutamate release when measured 24 h after the last stress session. Chronic treatment also caused a significant decrease in [3H]glutamate binding to hippocampal membranes. We suggest that changes in the glutamatergic system are likely to take part in the mechanisms involved in nervous system plasticity following repeated stress exposure.

Citing Articles

Molecular, Pathophysiological, and Clinical Aspects of Corticosteroid-Induced Neuropsychiatric Effects: From Bench to Bedside.

Sofia-Avendano-Lopez S, Rodriguez-Marin A, Lara-Castillo M, Agresott-Carrillo J, Lara-Cortes L, Sanchez-Almanzar J Biomedicines. 2024; 12(9).

PMID: 39335644 PMC: 11429036. DOI: 10.3390/biomedicines12092131.

Effects of prolonged escitalopram administration on long-term potentiation within the hippocampal CA1 area in rats under predictable and unpredictable chronic mild stress.

Marghmaleki V, Radahmadi M, Alaei H, Khanahmad H Metab Brain Dis. 2024; 39(8):1481-1494.

PMID: 39240474 DOI: 10.1007/s11011-024-01399-4.

A nutrigenomics approach to study the effects of ω-3 fatty acids in laying hens under physiological stress.

Berenjian A, Bakhtiarizadeh M, Mohammadi-Sangcheshmeh A, Sharifi S Front Physiol. 2023; 14:1198247.

PMID: 37560158 PMC: 10407228. DOI: 10.3389/fphys.2023.1198247.

Effects of datumetine on hippocampal NMDAR activity.

Ishola A, Imam A, Ajao M Toxicol Rep. 2021; 8:1131-1142.

PMID: 34150523 PMC: 8190477. DOI: 10.1016/j.toxrep.2021.05.009.

Korean Red Ginseng reduces chronic social defeat stress-induced mood disorders via N-methyl-D-aspartate receptor modulation in mice.

Lee B, Lee J, Ko Y, Seo J, Hur K, Kim Y J Ginseng Res. 2021; 45(2):254-263.

PMID: 33841006 PMC: 8020286. DOI: 10.1016/j.jgr.2019.11.003.

References

Jones D, Matus A . Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation. Biochim Biophys Acta. 1974; 356(3):276-87. DOI: 10.1016/0005-2736(74)90268-5. View

Zhu B, Zhu D, Chen Y . Rapid enhancement of high affinity glutamate uptake by glucocorticoids in rat cerebral cortex synaptosomes and human neuroblastoma clone SK-N-SH: possible involvement of G-protein. Biochem Biophys Res Commun. 1998; 247(2):261-5. DOI: 10.1006/bbrc.1998.8772. View

Rothstein J, Pardo C, Bristol L, Jin L, Kuncl R, Kanai Y . Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 1996; 16(3):675-86. DOI: 10.1016/s0896-6273(00)80086-0. View

McEwen B, de Kloet E, Rostene W . Adrenal steroid receptors and actions in the nervous system. Physiol Rev. 1986; 66(4):1121-88. DOI: 10.1152/physrev.1986.66.4.1121. View

Dunkley P, Heath J, Harrison S, Jarvie P, Glenfield P, Rostas J . A rapid Percoll gradient procedure for isolation of synaptosomes directly from an S1 fraction: homogeneity and morphology of subcellular fractions. Brain Res. 1988; 441(1-2):59-71. DOI: 10.1016/0006-8993(88)91383-2. View

Woolley C, Gould E, McEwen B . Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. Brain Res. 1990; 531(1-2):225-31. DOI: 10.1016/0006-8993(90)90778-a. View

Halpain S, McEwen B . Corticosterone decreases 3H-glutamate binding in rat hippocampal formation. Neuroendocrinology. 1988; 48(3):235-41. DOI: 10.1159/000125017. View

Marti O, Gavalda A, JOLIN T, Armario A . Effect of regularity of exposure to chronic immobilization stress on the circadian pattern of pituitary adrenal hormones, growth hormone, and thyroid stimulating hormone in the adult male rat. Psychoneuroendocrinology. 1993; 18(1):67-77. DOI: 10.1016/0306-4530(93)90056-q. View

Gilad G, Gilad V, Wyatt R, Tizabi Y . Region-selective stress-induced increase of glutamate uptake and release in rat forebrain. Brain Res. 1990; 525(2):335-8. DOI: 10.1016/0006-8993(90)90886-g. View

10.

McEwen B . Stress and hippocampal plasticity. Annu Rev Neurosci. 1999; 22:105-22. DOI: 10.1146/annurev.neuro.22.1.105. View

11.

Danbolt N . Glutamate uptake. Prog Neurobiol. 2001; 65(1):1-105. DOI: 10.1016/s0301-0082(00)00067-8. View

12.

Leal M, Emanuelli T, Porciuncula L, Souza D, Elisabetsky E . Ibogaine alters synaptosomal and glial glutamate release and uptake. Neuroreport. 2001; 12(2):263-7. DOI: 10.1097/00001756-200102120-00017. View

13.

Elliott E, Miller C, Schilling J, Newcombe R, Sapolsky R . Glucocorticoids exacerbate kainic acid-induced extracellular accumulation of excitatory amino acids in the rat hippocampus. J Neurochem. 1992; 58(5):1730-5. DOI: 10.1111/j.1471-4159.1992.tb10047.x. View

14.

McEwen B . Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging. 2002; 23(5):921-39. DOI: 10.1016/s0197-4580(02)00027-1. View

15.

Bassett J, CAIRNCROSS K, King M . Parameters of novelty, shock predictability and response contigency in corticosterone release in the rat. Physiol Behav. 1973; 10(5):901-7. DOI: 10.1016/0031-9384(73)90060-7. View

16.

Landfield P, Eldridge J . The glucocorticoid hypothesis of brain aging and neurodegeneration: recent modifications. Acta Endocrinol (Copenh). 1991; 125 Suppl 1:54-64. View

17.

Magarinos A, McEwen B . Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors. Neuroscience. 1995; 69(1):89-98. DOI: 10.1016/0306-4522(95)00259-l. View

18.

Hashiguchi H, Ye S, Morris M, Alexander N . Single and repeated environmental stress: effect on plasma oxytocin, corticosterone, catecholamines, and behavior. Physiol Behav. 1997; 61(5):731-6. DOI: 10.1016/s0031-9384(96)00527-6. View

19.

Lachuer J, Delton I, Buda M, Tappaz M . The habituation of brainstem catecholaminergic groups to chronic daily restraint stress is stress specific like that of the hypothalamo-pituitary-adrenal axis. Brain Res. 1994; 638(1-2):196-202. DOI: 10.1016/0006-8993(94)90650-5. View

20.

Cancela L, Bregonzio C, Molina V . Anxiolytic-like effect induced by chronic stress is reversed by naloxone pretreatment. Brain Res Bull. 1995; 36(3):209-13. DOI: 10.1016/0361-9230(94)00185-4. View