» Articles » PMID: 15328137

Drug Susceptibility and Genetic Evaluation of Plasmodium Falciparum Isolates Obtained in Four Distinct Geographical Regions of Kenya

Abstract

The drug resistance profiles of Plasmodium falciparum isolated from four regions in Kenya were analyzed for drug resistance profiles. We observed variability in resistance to a broad range of antimalarial drugs across Kenya as determined from in vitro drug susceptibility screening and genotyping analysis.

Citing Articles

Increased sensitivity of malaria parasites to common antimalaria drugs after the introduction of artemether-lumefantrine: Implication of policy change and implementation of more effective drugs in fight against malaria.

Okore W, Ouma C, Okoth R, Yeda R, Ingasia L, Mwakio E PLoS One. 2024; 19(6):e0298585.

PMID: 38900782 PMC: 11189199. DOI: 10.1371/journal.pone.0298585.


The Walter Reed Project, Kisumu Field Station: Impact of Research on Malaria Policy, Management, and Prevention.

Sifuna P, Mbinji M, Lucas T, Onyango I, Akala H, Waitumbi J Am J Trop Med Hyg. 2024; 110(6):1069-1079.

PMID: 38653233 PMC: 11154051. DOI: 10.4269/ajtmh.23-0115.


In vitro activity of rhinacanthin analogues against drug resistant Plasmodium falciparum isolates from Northeast Thailand.

Chaorattanakawee S, Kosaisavee V, Bunsermyos W, Aonsri C, Imaram W, Suwannasin K Malar J. 2023; 22(1):105.

PMID: 36959593 PMC: 10035203. DOI: 10.1186/s12936-023-04532-3.


Efficacy of three anti-malarial regimens for uncomplicated Plasmodium falciparum malaria in Cambodia, 2009-2011: a randomized controlled trial and brief review.

Lek D, Rachmat A, Harrison D, Chin G, Chaoratanakawee S, Saunders D Malar J. 2022; 21(1):259.

PMID: 36071520 PMC: 9450427. DOI: 10.1186/s12936-022-04279-3.


The Multistage Antimalarial Compound Calxinin Perturbates Ca Homeostasis by Targeting a Unique Ion Channel.

Gupta Y, Sharma N, Singh S, Romero J, Rajendran V, Mogire R Pharmaceutics. 2022; 14(7).

PMID: 35890267 PMC: 9319510. DOI: 10.3390/pharmaceutics14071371.


References
1.
Sibley C, Hyde J, Sims P, Plowe C, Kublin J, Mberu E . Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?. Trends Parasitol. 2002; 17(12):582-8. DOI: 10.1016/s1471-4922(01)02085-2. View

2.
Wellems T, Plowe C . Chloroquine-resistant malaria. J Infect Dis. 2001; 184(6):770-6. DOI: 10.1086/322858. View

3.
Kublin J, Dzinjalamala F, Kamwendo D, Malkin E, Cortese J, Martino L . Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. J Infect Dis. 2002; 185(3):380-8. DOI: 10.1086/338566. View

4.
Wongsrichanalai C, PicKard A, Wernsdorfer W, Meshnick S . Epidemiology of drug-resistant malaria. Lancet Infect Dis. 2002; 2(4):209-18. DOI: 10.1016/s1473-3099(02)00239-6. View

5.
Sidhu A, Verdier-Pinard D, Fidock D . Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science. 2002; 298(5591):210-3. PMC: 2954758. DOI: 10.1126/science.1074045. View