Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2004 Aug 12

PMID 15304631

Citations 331

Authors

Gregg L Semenza

Affiliations

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Abstract

The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression.

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