Human Herpesvirus 6 Infection of the Central Nervous System

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2004 Jul 22

PMID 15265461

Citations 4

Authors

Mary T Caserta

Affiliations

Soon will be listed here.

Abstract

Human herpesvirus (HHV) 6 infects all children, usually during the first year of life. High fever is the hallmark of primary infection, with febrile seizures the most common complication. After primary infection, HHV-6 remains latent or persistent at multiple sites, with intermittent reactivation. Many disorders of the central nervous system (CNS) have been linked to HHV-6 reactivation, including chronic seizure disorders, encephalitis, and demyelinating disorders including multiple sclerosis. Although multiple studies have pieced together an understanding of the molecular organization, viral characteristics, immunology, and epidemiology of HHV-6, the true role of this virus in diseases of the CNS is still unfolding.

Citing Articles

A case of bilateral human herpes virus 6 panuveitis with genomic viral DNA integration.

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Chronic viral infection and primary central nervous system malignancy.

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Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low grade gliomas.

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Detection of human herpesvirus-6 in adult central nervous system tumors: predominance of early and late viral antigens in glial tumors.

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