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Identification of Human Herpesvirus-6 As a Causal Agent for Exanthem Subitum

Overview
Journal Lancet
Publisher Elsevier
Specialty General Medicine
Date 1988 May 14
PMID 2896909
Citations 369
Authors
Affiliations
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Abstract

A virus was isolated from the peripheral blood lymphocytes of patients with exanthem subitum, cultured successfully in cord blood lymphocytes, and shown to be antigenically related to human herpesvirus-6 (HHV-6). Morphological features, as studied by thin-section electronmicroscopy, resembled those of herpes group viruses. Convalescent-phase serum samples, tested against the new viral antigen and HHV-6 antigen, showed seroconversion. The results strongly suggest that the newly isolated virus is identical or closely related to HHV-6 and the causal agent for exanthem subitum.

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