In Situ Hybridization Detection of Human Herpesvirus 6 in Brain Tissue from Fatal Encephalitis

Overview

Journal Pediatrics

Specialty Pediatrics

Date 2000 Feb 2

PMID 10654970

Citations 5

Authors

S Ahtiluoto

L Mannonen

A Paetau

A Vaheri

M Koskiniemi

P Rautiainen

M Muttilainen

Affiliations

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Abstract

A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase chain reaction for HHV-6 of serum and paraffin-embedded pontine tissue was positive, and serology indicated an acute primary infection. This is the first case showing HHV-6 DNA in the brain cells of an immunocompetent patient with acute encephalitis.

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